PSD95 Antibody 2507S from Cell Signaling Technology

Product Specs
ItemPSD95 Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number2507S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R
TargetPSD-95
HostRabbit
NCBI Gene AliasesMRD62, PSD95, SAP-90, SAP90
NCBI Full Gene Namediscs large MAGUK scaffold protein 4
ClonalityPolyclonal
Research AreaNeuroscience
Molecular Weight95

Questions and Answers

Can this PSD95 antibody be used for immunocytochemistry in mouse models?

Yes, the PSD95 antibody has been utilized in immunocytochemistry applications, as demonstrated in studies such as where it was employed to analyze synaptic proteins in cultured cortical neurons.

Is the PSD95 antibody effective for Western blotting in detecting synaptic proteins?

The PSD95 antibody has been shown to work effectively in Western blotting, as evidenced by its use in various studies, including and , where it was used to analyze protein levels in different experimental contexts.

What species can this antibody detect, and has it been cited in relevant research?

The PSD95 antibody is reactive with mouse, human, and rat proteins. It has been cited in 138 scientific articles, indicating its widespread use in neuroscience research, including studies on synaptic plasticity and neurodevelopmental disorders.

Are there any specific applications where this antibody has been highlighted in recent studies?

Recent studies, such as and , have highlighted the use of the PSD95 antibody in examining synaptic signaling pathways and synaptic remodeling, showcasing its relevance in understanding mechanisms underlying neurological conditions.

Cell Signaling Technology

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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Tuberostemonine ameliorates Alzheimer's disease pathology by suppression of the p38 MAPK signaling pathwayiScienceAugust 21, 2026Yingzhou Li, Xiaoxia Xu, Ziyao Meng, Linjie Chen, Qin Yu, Ruya Wang, Yiyu Ren, Fan Chen, Guang Liang, Xia Zhao, et al.,Cell Signaling Technology,Cat# 2450; RRID:AB_490857 Rabbit monoclonal Anti-PSD95,Cell Signaling Technology,Cat# 2507; RRID:AB_561221 Rabbit monoclonal Anti-Phospho-Tau (Thr217),Cell Signaling Technology,Cat# 51625; RRID:AB_3068604 Mouse

(2) Aberrant CX3CL1-CX3CR1 Signaling Reprograms Microglial Exosome Secretion via KIFC2 to Drive Cognitive Impairment in Chronic PainInt J Mol SciJuly 15, 2026Chen Hu, Xinlu Zhang, Wei Zhao, Wenjun Ke, Haoxiang Ma, Wenna Sang, Qian Gaoprimary antibodies against CX3CR1 (1:2000, PC1728S, Abmart, Berkeley Heights, NJ, USA), PSD95 (1:2000, 2507S, CST, Danvers, MA, USA), p-p65 (1:1000, 3033T, CST), p-p38 (1:1000, 9211S, CST), p38 (1:1000, T40075S,

(3) Prenatal immune activation and adult Poly(I:C) re-challenge promote neuroimmune priming and AD-related behavioural, cellular and molecular alterations in wild-type miceFront ImmunolJuly 8, 2026Giacomo Giacovazzo, Valentina Latina, Zuleyha Nihan Yurtsever, Iliana Piccolino, Filomena Iannuzzi, Paola Bossù, Giuseppina Amadoro, Roberto CoccurelloAdaptor molecule 1 (Iba1) rabbit 019–19741 Wako; anti-PostSynaptic Density Protein 95 (PSD95) rabbit 2507 Cell Signaling; anti-syntaxin 1 mouse S1172 Sigma-Aldrich; anti-Synaptosomal-Associated Protein 25kDa

(4) Aged circulating CD8+ T cells and their secreted factors drive cognitive declineImmunityJune 9, 2026Juliana Sucharov, Gregor Bieri, Karishma J.B. Pratt, Amber R. Philp, Turan Aghayev, Shanan Sahota, Laura Remesal, Adam B. Schroer, Cedric E. Snethlage, Rebecca Chu, et al.(1:1000, Sigma Millipore, 07-632), anti-NR2B (1:4000, Abcam, ab65783), anti-PSD95 (1:500, Cell Signaling, 2507S), anti-Homer1 (1:500, Invitrogen, PA5-21487), or anti-ZO1 (TJP1) (1:500, ThermoFisher Scientific, 40-2200).

(5) PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive functionSci AdvMay 15, 2026Jia Tong, Yang Liu, Wanliu Wu, Qianqian Wang, Huifang Yang, Junyao Li, Ziyan Gao, Weizhen Liu, Jie Liu, Paul Chazot, et al.(21760-1-Ig, Proteintech), anti-glutamate receptor 1 (AMPA subtype) (ab109450, Abcam), anti-PSD 95 (#2507S; Cell Signaling Technology), anti-SAP102 (S19-2) (MA5-27707, Invitrogen), anti-DDDDK-Tag (AE024, Abclonal),

(6) Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAsAdvanced ScienceApril 28, 2026Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, et al.was as follows: rabbit anti‐BDNF (Abcam) (ab108319; 1:1,000 for blotting); rabbit anti‐PSD95 (CST)(2507; 1:1000 for blotting); rabbit anti‐GABAAα1(Millipore)(06‐868; 1:2000 for blotting); rabbit anti‐ GABAAβ1/2/3

(7) A small-molecule stabilizer of the calpastatin-calpain-2 complex restores mitochondrial function and mitigates neurodegenerationSci AdvMarch 27, 2026Di Hu, Xiaoyan Sun, Yutong Shang, Kathleen Lundberg, Drew J. Adams, Xin QiMilliporeSigma, 1:10000), anti-DLP1 (611113, BD Bioscience, Franklin Lakes, NJ, USA, 1:2000), anti-PSD95 (2507, Cell Signaling Technology, Danvers, MA, USA, 1:5000), anti–Drp1-pS616 (3455S, Cell Signaling Technology,

(8) Effects of Short-Term Exposure to Polystyrene Nanoplastics on the Nervous System: Calcium Homeostasis, BDNF and Synaptic PlasticityToxicsFebruary 17, 2026Yiming Zhao, Licheng Yan, Yizhe Wei, Jianping Ma, Jiang Chen, Xuan Liu, Yanan Mi, Bingyan Wang, Leili Zhang, Lei Tian, et al.12208-1-AP, Proteintech, Rosemont, IL, USA), BDNF (1:1000, ab226843, abcam, Cambridge, UK), PSD95 (1:1000, 2507S, CST), SYN (1:2000, 17785-1-AP, Proteintech), ProBDNF (1:1000, 28205-1-AP, Proteintech), and GAPDH (1:2000,

(9) Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced depression and anxiety behavior in miceTranslational PsychiatryFebruary 3, 2026Jia Liu, Yan Lu, Piplu Bhuiyan, Jacob Gruttner, Lauren St. Louis, Yutong Yi, Ge Liang, Huafeng Wei,1:1 000 Anti-IL-1β,"31202S, Cell signaling Technology, USA",1:1 000 Anti-IL-18,10663-1-AP; Proteintech,1:3 000 Anti-PSD95,"#2507; Cell signaling Technology, USA",1:1 000 Anti-Synapsin-1,"#5297; Cell signaling Technology, USA",1:1 000

(10) Therapeutic Effects of Noninvasive Electrical Stimulation in Combination Transplantation of Human Adipose‐Derived Stem Cells‐Derived Dopaminergic Neuron on the Monkey Model of Parkinson's DiseaseMedComm (2020)February 1, 2026Chunhui Huang, Shane Gao, Xiao Zheng, Xichen Song, Jiaxi Wu, Kai Liao, Jiawei Li, Yingqi Lin, Caijuan Li, Yaqun Lu, et al.OPA1 (CST; 80471S), DRP1 (abcam; ab56788), Fis1 (CST; 32525S), NeuN (abcam; ab177487), PSD95 (CST; 2507S), synapsin‐1 (CST; 5297S), synaptophysin (CST; 25056S), Iba1 (abcam; ab178846), GFAP (Invitrogen; 13‐0300),

(11) Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpressionJournal of NeuroinflammationJanuary 7, 2026Kan Xie, Devon Ryan, Susanne Schröder, Lena Freund, Stefan Bonn, Yu Zhou, Dan EhningerCambridge, UK), rabbit polyclonal anti-SLC5A7 (#ab135043, 1:3,000; Abcam), rabbit polyclonal anti-PSD95 (#2507, 1:2,000; Cell Signaling Technology), mouse monoclonal anti-synaptophysin (#ab8049, clone SY38, 1:2,000;

(12) Relief from Chronic Unpredictable Mild Stress-Induced Constipation by Fluoxetine and Butyrate and Their Impact on Gut MicroecologyDrug Des Devel TherDecember 26, 2025Xuzhao Li, Jing Suo, Shiqin Yao, Bowen Tian, Zhifeng Zhao, Yanrong Wang, Xiaoliang Li, Dingding Jin, Xiaoran Yang(Cell signaling, #2971,1:1000), anti-BDNF antibody (Cell signaling, #47808, 1:1000), anti-PSD-95 (Cell signaling, #2507,1:1000), anti-Synapsin 1 (Cell signaling, #5297,1:1000), anti-GluR1 (Cell signaling, #13185,1:1000),

(13) Relief from Chronic Unpredictable Mild Stress-Induced Constipation by Fluoxetine and Butyrate and Their Impact on Gut MicroecologyDrug Des Devel TherDecember 26, 2025Xuzhao Li, Jing Suo, Shiqin Yao, Bowen Tian, Zhifeng Zhao, Yanrong Wang, Xiaoliang Li, Dingding Jin, Xiaoran Yang(Cell signaling, #2971,1:1000), anti-BDNF antibody (Cell signaling, #47808, 1:1000), anti-PSD-95 (Cell signaling, #2507,1:1000), anti-Synapsin 1 (Cell signaling, #5297,1:1000), anti-GluR1 (Cell signaling, #13185,1:1000),

(14) Sevoflurane Exposure Exacerbates Memory Impairment and Pathological Manifestation by Inhibiting AKT/mTOR-Mediated Autophagy in P301L Tau Transgenic MiceCNS Neurosci TherDecember 17, 2025Kaiwu He, Zhijing Zhang, Youzhi Li, Wei Xiong, Yanmei Xing, Wenli Gao, Wei Kong, Lixin Chen, Xifei Yang, Zhongliang DaiAntibody,Cat.,Type,Application,Source AT8,MN1020,Mouse,WB/IF,Thermo AT180,MN1040,Mouse,WB/IF,Thermo AT270,MN1050,Mouse,WB,Thermo Tau 5,ab80579,Mouse,WB,Abcam PSD95,2507S,Rabbit,WB,Cell Signaling Technology Synapsin‐1,ab254349,Rabbit,WB,Abcam SNAP25,ab109105,Rabbit,WB,Abcam Syn,ab32127,Rabbit,WB,Abcam GFAP,MAB360,Mouse,WB/IF,Merck Iba1,"019–19,741",Rabbit,WB/IF,Wako Sort1,A7926,Rabbit,WB,ABclonal Vps28,A9104,Rabbit,WB,ABclonal Atg3,A5809,Rabbit,WB,ABclonal p62,ab109012,Rabbit,WB/IF,Rabbit p‐AKT,4060S,Rabbit,WB,Cell Signaling Technology

(15) Early branched-chain amino acid reduction delays the onset of cognitive decline in a mouse model of Alzheimer's diseaseJournal of Alzheimer’s DiseaseDecember 1, 2025Caitlyn A Mullins, Ritchel B Gannaban, Alyssa Kramer, Harsh Shah, Zobayda Farzana Haque, Marjan Ramezan, Fereshteh Dehghani, Arun Kumar Palaniyappan, Frances Bowers, Sheba MJ MohanKumar, et al.(Cell Signaling, Cat# 65534S), Synaptophysin (Cell Signaling, Cat# 5461S), PSD95 (Cell Signaling, Cat # 2507S), GAPDH (Cell Signaling, Cat# 2118S), and Vinculin (Cell Signaling, Cat# 13901S). Next day, the membrane

(16) The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant actionNature CommunicationsNovember 26, 2025Stefan Vestring, Maxime Veleanu, Marina Conde Perez, Louise E. Schuberth, Martin Bronnec, Anna Li, Lovis M. Würz, Fatih Erdogdu, Julia Stocker, Johanna Moos, et al.anti-GluA1-NT (Millipore, USA, MAB2263, 1:2000, #3847897), rabbit anti-PSD95 (Cell Signaling, USA, 2507, 1:2000, lot #4), Anti p44/42 MAPK (ERK1/2) antibody (Cell Signaling, USA, 9102, 1:10000, lot #30),

(17) Response of iPSC-derived neurons from individuals with treatment-resistant depression to (2 R,6 R)-hydroxynorketamine and reelin: an exploratory studyTranslational PsychiatryNovember 18, 2025Jenessa N. Johnston, Peixiong Yuan, Bashkim Kadriu, Nirmala Akula, Brandi Quintanilla, Shiyong Peng, Greg H. Jones, Anton Schulmann, Mani Yavi, Ioline D. Henter, et al.phosphorylated protein for mTOR (#2972S, CST) and ERK (#5376S, CST). Other proteins analyzed were PSD-95 (#2507S, CST), Synapsin I (#6710, CST), GluA1 (#13185S, CST), Dab1 (#3328S, CST), TrkB (#4603S, CST), and NR2B

(18) Abnormal behaviors and glial responses in an animal model of tau pathologyMolecular BrainNovember 6, 2025Yue Liu, Akira Sobue, Naruhiko Sahara, Madoka Isobe, Rinako Tanaka, Youyun Zhu, Wenjun Zhu, Tetsuo Matsuzaki, Koji Yamanaka, Kiyofumi Yamada, et al.USA), rabbit anti–phospho-Tau (Ser214) (#77,348, diluted 1:1000; Cell Signaling), rabbit anti–PSD95(2507S, diluted 1:1000; Cell Signaling), and rabbit anti–synapsin (AB1543P, diluted 1:1000; Millipore) at 4

(19) Fermented Soybean Pulp Alleviates Disease Progression of 5×FAD Model MiceMolecular neurobiologyNovember 1, 2025Yang CY, Liu YH, Lin TC, Chang KH, Hsieh-Li HM.(WB) SOD1,Santa cruz,sc-11407,1:1000 (WB) SOD2,Millpore,06–984,1:1000 (WB) PSD95,Cell Signaling,2507S,1:1000 (WB) Synaptophysin,Abcam,ab14692,1:1000 (WB) BDNF,Abcam,ab108319,1:1000 (WB) GSK3β,Cell Signaling,9315S,1:1000

(20) Rutin ameliorates sevoflurane-induced neurotoxicity by inhibiting microglial synaptic phagocytosis through the complement pathwaySci RepOctober 30, 2025Xinyu Tian, Miaomiao Xiong, Zhiguo Jiang, Rong Hong, Honghua Wang4 °C: rabbit anti-PSD95 (Postsynaptic density protein-95, PSD95)(1:500; Cell Signaling Technology, 2507), rabbit anti-Vglut2 (Vesicular glutamate transporter 2, Vglut2)(1:1000; Synaptic Systems, 135402),

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2/4/2021PSD95 Antibody for Immunoblotting Chao YangI have been using this antibody for several years to detect PSD95 proteins in various cell lines using Immunoblotting.

PSD95 Antibody

PSD95 Antibody from Cell Signaling Technology

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PSD95 Antibody from Cell Signaling Technology

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