Syk Antibody 2712S from Cell Signaling Technology

Product Specs
ItemSyk Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number2712S
Quantity100 µl
TargetSyk
HostRabbit
NCBI Gene AliasesIMD82, p72-Syk
NCBI Full Gene Namespleen associated tyrosine kinase
ApplicationsW
ReactivityH, M
ClonalityPolyclonal
Research AreaImmunology and Inflammation
Molecular Weight72

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Cytoskeletal Protein 4.1R Inhibits BCR-Mediated B-Cell Activation by Restraining AKT1 PhosphorylationCellsJuly 13, 2026Yuying Guo, Dandan Fan, Denghui Liu, Qi Shao, Siyao Sang, Yuting Niu, Lixiang Chen, Taotao Liang1:1000), anti-Phospho-GSK3β (9323, Cell Signaling Technology, Danvers, MA, USA; 1:1000), anti-SYK (2712, Cell Signaling Technology, Danvers, MA, USA; 1:1000), anti-Phospho-SYK (44170, Cell Signaling Technology,

(2) Differential regulation of monocyte exhaustion by distinct TLR agonists and underlying mechanismsCell Communication and SignalingMay 20, 2026Jing Wang, Yajun Wu, Grace Lee, Babak Razani, Liwu LiPhospho-Src (Cell Signaling, #2105), total-Src (Cell Signaling, #2110), total-Syk (Cell Signaling, #2712), S6K(P70) (Proteintech, #4485-1-AP), Phospho-4E-BP1 ( Cell Signaling, #9644), 4E-BP1 (Cell Signaling,

(3) Sustained monocyte activation by persistent challenges with either oxLDL or free cholesterol and underlying mechanismsImmunoHorizonsFebruary 24, 2026Yajun Wu, Shuo Geng, Grace Atkinson, Blake Caldwell, Jing Wang, Liwu Liovernight at 4 °C with primary antibodies Src (Cell Signaling, no. 2108), SYK (Cell Signaling, no. 2712), p70S6K (Proteintech, no. 14485-1-AP), STAT1 (Cell Signaling, no. 9172), STAT3 (Cell Signaling, no.

(4) Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylationLife Sci AllianceFebruary 4, 2026Maxime Jansen, Jean-Marc Strub, Laurent Chaloin, Peter Coopman, Bruno Beaumelleon 10% acrylamide gels before Western blot. Syk was stained using rabbit polyclonal anti-Syk (CST# 2712) followed by mouse anti-rabbit light chain-peroxidase. Syk phosphorylation on mSyk-Tyr519/520 was followed

(5) Paeoniflorin Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by SYK/SH3BP2 Signaling PathwayResearch (Wash D C)February 2, 2026Yuqing Liu, Jie Tao, Dongyu Tan, Feifan Zheng, Zhuoxuan Su, Jianfeng Yuan, Chunmei Zhu, Zhensen Zheng, Xiuteng Zhou, Duosheng LuoProteintech, 1:20,000), GAPDH (60004-1-IG, Proteintech, 1:6,000), Phospho-Syk (2710T, CST, 1:1,000), Syk (2712T, CST, 1:1,000), SH3BP2 (PA5-87739, Invitrogen, 1:1,000), Goat anti-Mouse IgG Secondary Antibody HRP

(6) Natural killer cell-specific chimeric antigen receptor enhances CAR NK cell functions and anti-tumor activityTheranosticsNovember 6, 2025Changqing Pan, You Zhai, Zhongliang Cui, Yiyun Yin, Menghui Xu, Di Wang, Yishuo Sun, Jiazheng Zhang, Chen Wang, Ziwei Li, et al.antibodies: SYK (Tyr525/526; Cell Signaling Technology, Cat# 2710), SYK (Cell Signaling Technology, Cat# 2712), ZAP70 (Tyr319; Cell Signaling Technology, Cat# 2701), ZAP70 (Cell Signaling Technology, Cat# 2705),

(7) Lymphoid gene expression supports neuroprotective microglia functionNatureNovember 5, 2025Pinar Ayata, Jessica M. Crowley, Matthew F. Challman, Vinaya Sahasrabuddhe, Maud Gratuze, Sebastian Werneburg, Diogo Ribeiro, Emma C. Hays, Violeta Durán-Laforet, Travis E. Faust, et al.provided in Supplementary Figs. 9–11. The primary antibodies used were Syk (Cell Signaling Technology; 2712; 1:500), phospho-Syk Y352 (Cell Signaling Technology; 2717; 1:500), PLCG2 (Cell Signaling Technology;

(8) AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progressionNat CommunJuly 29, 2025Qiaohua Wang, Yongjian Wu, Yili Long, Rongna Li, Yu Shi, Yanfen Zheng, Xiaohui Chen, Xiang Li, Yihong Zhou, Xi Huang, et al.Stat3 (79D7) Rabbit mAb (Cell Signalling Technology, 4904, 1:1000), Anti-Syk Antibody (Cell Signalling Technology, 2712, 1:1000), Phospho-Syk (Tyr525/526) (C87C1) mAb (Cell Signalling Technology, 2710, 1:1000), ROR gamma

(9) Unique compound with anti-allergic action: inhibition of Lyn kinase activity by KIRA6Front PharmacolJuly 25, 2025Goshi Matsushima, Yuri Matsui, Hanano Okamoto, Nagisa Umeda, Mai Kakimoto, Megumi Mino, Tadashi Nakagawa, Kaori Ishii, Yoshimi Matsuo, Daiki Matsubara, et al.membrane, as previously described (Hiragun et al., 2013). Immunoblotting was performed using anti-Syk (#2712; Cell Signaling) and anti-phospho Syk (Tyr525/526; #2710; Cell Signaling) antibodies at 4 °C overnight.

(10) Drug screening targeting TREM2-TYROBP transmembrane bindingMol MedMay 5, 2025M. Cobas-Carreño, A. Esteban-Martos, L. Tomas-Gallardo, I. Iribarren, L. Gonzalez-Palma, A. Rivera-Ramos, J. Elena-Guerra, E. Alarcon-Martin, R. Ruiz, M. J. Bravo, et al.then incubated with the different antibodies overnight at 4 °C (anti-hSYK #2710, anti-hPhospho-SYK #2712 from Cell Signaling were used according to manufacturer’s instructions), followed by incubation with

(11) Ganglioside GT1b prevents selective spinal synapse removal following peripheral nerve injuryEMBO ReportsApril 30, 2025Jaesung Lee, Kyungchul Noh, Subeen Lee, Kwang Hwan Kim, Seohyun Chung, Hyoungsub Lim, Minkyu Hwang, Joon-Hyuk Lee, Won-Suk Chung, Sunghoe Chang, et al.101319 Phospho-SYK (Tyr525/526) antibody,Cell Signaling,Cat# 2710T SYK antibody,Cell Signaling,Cat# 2712T Rabbit monoclonal GAPDH-antibody,Cell Signaling,Cat # 5174S "Goat anti-rabbit IgG (H + L)Secondary

(12) Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer's diseaseSci RepApril 3, 2025Rezwanul Islam, Hadi Hasan Choudhary, Feng Zhang, Hritik Mehta, Jun Yoshida, Ajith J. Thomas, Khalid HanafyCST, Cat# 2796S), rabbit anti-phospho-Syk (1:1000, CST, Cat# 2710), rabbit anti-Syk (1:1000, CST, Cat# 2712), rabbit anti-pi3k (1:1000, CST, Cat# 4292), rabbit anti-Akt (1:1000, CST, Cat# 4691), rabbit anti-phospho-Akt

(13) Platelet glycoprotein VI promotes folic acid-induced acute kidney injury through interaction with tubular epithelial cell-derived galectin-3Cell Commun SignalMarch 21, 2025Ya-Wei Guo, Qi Luo, Meng Lu, Xiang-Bin Zeng, Yu-Min Zhang, Yue-Ling Lin, Xu-Ran Guo, Rong Ma, Zhang-Yin MingUSA) 1:1000, p-PLCγ2 (Cell Signaling Technology, 3871, USA) 1:1000, Syk (Cell Signaling Technology, 2712, USA) 1:1000, p-Syk (Cell Signaling Technology, 2710, USA) 1:1000, JAQ1 (emfret, M011-0, Germany) 1:1000,

(14) The late-onset Alzheimer's disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysisLife Sci AllianceMarch 13, 2025Georg Jocher, Gozde Ozcelik, Stephan A Müller, Hung-En Hsia, Miranda Lastra Osua, Laura I Hofmann, Marlene Aßfalg, Lina Dinkel, Xiao Feng, Kai Schlepckow, et al.rat IgG2b APC-conjugated isotype control antibody was from Bio-Techne (0.4 μg/106 cells, IC013A). For detection of Syk, a rabbit anti-Syk (2712; Cell Signaling) was used at 1:1,000, and phospho-Syk was detected using rabbit anti-phospho-Syk (C87C1)

(15) Phosphorylation of (Ser 291) in the linker insert of Syk negatively regulates ITAM signaling in plateletsPlateletsDecember 31, 2024Carol Dangelmaier, Hymavathi Reddy Vari, Dhruv N Vajipayajula, Manal Elzoheiry, Monica Wright, Ashvin Iyer, Alexander Y Tsygankov, Satya P Kunapuliplatelets was confirmed by probing with a Syk rabbit polyclonal antibody from Cell Signaling (cat# 2712) which was raised against a peptide surrounding aa 628 in the c-terminal and Syk (cat#31398) which was

(16) Discovery of Carbonic Anhydrase 9 as a Novel CLEC2 Ligand in a Cellular Interactome ScreenCellsDecember 17, 2024Hoffmann S, Berger BT, Lucas LR, Schiele F, Park JE.were diluted 1:20 for simple Western. For anti-Syk/Phospho-Syk (cell signaling, Leiden, Netherlands, #2712S and #2711S), simple Western, Ramos-Blue™ and HCT 116 cells (9:1 ratio) were incubated for 15 min at

(17) Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraineJournal of NeuroinflammationDecember 3, 2024Zhenzhen Fan, Dandan Su, Zi Chao Li, Songtang Sun, Zhaoming GeUK",ab305103,Rabbit,1:1000 c-fos,"Santa Cruz, USA",sc166940,Mouse,1:500 CGRP,"Abcam, UK",ab139264,Rabbit,1:1000 SYK,"CST, USA",2712,Rabbit,1:1000 p-SYK,"CST, USA",2710,Rabbit,1:1000 NLRP3,"CST, USA","15,101",Rabbit,1:1000 ASC,"CST,

(18) Gain-of-Function Variant in Spleen Tyrosine Kinase Regulates Macrophage Migration and Functions to Promote Intestinal InflammationJournal of Inflammation ResearchNovember 12, 2024Ye Yang, Lin Wang, Zhiyang Zeng, Chunmeng He, Yanqiu Wang, Ying Huang°C. The membrane was further incubated overnight at 4 °C with primary antibodies against Syk (1:1000, 2712T, Cell Signaling Technology, Danvers, MA, USA), pSyk (1:1000, AF8404, Affinity Biosciences), NLRP3 (1:1000,

(19) Gain-of-Function Variant in Spleen Tyrosine Kinase Regulates Macrophage Migration and Functions to Promote Intestinal InflammationJ Inflamm ResNovember 12, 2024Ye Yang, Lin Wang, Zhiyang Zeng, Chunmeng He, Yanqiu Wang, Ying Huang°C. The membrane was further incubated overnight at 4 °C with primary antibodies against Syk (1:1000, 2712T, Cell Signaling Technology, Danvers, MA, USA), pSyk (1:1000, AF8404, Affinity Biosciences), NLRP3 (1:1000,

(20) Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infectionmBioOctober 16, 2024Mary Clark H. Lind, Waheeda A. Naimi, Travis J. Chiarelli, Tavis Sparrer, Mallika Ghosh, Linda Shapiro, Jason A. Carlyonconditions followed the manufacturer’s recommendations and targeted Syk (1:1,000; Cell Signaling Technology [2712]), phospho-Syk (Tyr525/526; C87C1; 1:1,000; Cell Signaling Technology [2710]), Src (36D10; 1:1,000;

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Syk Antibody

Syk Antibody from Cell Signaling Technology

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Cell Signaling Technology

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Syk Antibody from Cell Signaling Technology

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