IGF-I Receptor beta (111A9) Rabbit mAb 3018S from Cell Signaling Technology

Product Specs
ItemIGF-I Receptor beta (111A9) Rabbit mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number3018S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R, Mk
TargetIGF1R beta
IsotypeIgG
HostRabbit
NCBI Gene AliasesCD221, IGFIR, IGFR, JTK13
NCBI Full Gene Nameinsulin like growth factor 1 receptor
Clone111A9
Molecular Weight95
ClonalityMonoclonal
Research AreaMetabolism

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signalingSci AdvMay 15, 2026Irena Selicharová, Nicholas S. Kirk, Anna Kertisová, Marta Lubos, Katarína Mitrová, Terezie Ticháčková, Lenka Žáková, Martina Chrudinová, Jana Březinová, Karel Harant, et al.(Cell Signaling Technology, catalog no. 3025) or anti–IGF-1R β (111A9) antibody (Cell Signaling Technology, catalog no. 3018). Anti-actin (20-33) antibody (Sigma-Aldrich, catalog no. A5060) was used as a loading control. Cell viability assay

(2) Autophagy-Induced Microglial Death Contributes to Neuroinflammation in Acute Optic Nerve InjuryInvest Ophthalmol Vis SciDecember 16, 2025Shuping Ke, Jiajian Liang, Wai Kit Chu, Yan Tong, Suyao Wu, Weiqing Ye, Shaolang Chen, Qingping Liu, Dingguo Huang, Weiqi Chen, et al.Cell Signaling Technology), anti-p-MLKL (Ser345, 1:1000; #37733; Cell Signaling Technology), anti-IGF1Rβ (1:2000; #3018S; Cell Signaling Technology), anti-p-IGF1Rβ (Tyr1135; 1:1000; #3918S; Cell Signaling), anti-p-AKT (Ser473,

(3) mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transportMolecular CellSeptember 18, 2025Sejeong Shin, Min-Joon Han, Ishika Patel, Alia M. Welsh, Maria Sverdlov, Wonhwa Cho, Stephanie M. Cologna, Philippe P. Roux, Sang-Oh YoonAB_390722" Anti-phospho-Y980-IGF1R,Cell Signaling Technology,"4568S, RRID: AB_2122279" Anti-IGF1R,Cell Signaling Technology,"3018, RRID: AB_560943" Anti-phospho-T202/Y204-ERK1/2,Cell Signaling Technology,"4370, RRID: AB_2315112" Anti-ERK1/2,Cell Signaling Technology

(4) GRP94 is an IGF-1R chaperone and regulates beta cell death in diabetesCell Death & DiseaseMay 29, 2024Do-Sung Kim, Lili Song, Wenyu Gou, Jisun Kim, Bei Liu, Hua Wei, Robin C. Muise-Helmericks, Zihai Li, Hongjun WangADI-SPA-850), IRE1a (Cell Signaling Technology, 3294 S), IGF-1Rβ (Cell Signaling Technology, 9750 S, 3018 S, 14534 S), IRβ (Cell Signaling Technology, 3020 S) 5625 P LC3A/B (Cell Signaling Technology, 12741

(5) Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activationOpen biologyNovember 1, 2023Kertisová A, Žáková L, Macháčková K, Marek A, Šácha P, Pompach P, Jiráček J, Selicharová I.antibody (Invitrogen, cat. no. AHR0271) or an anti- IGF-1R β (111A9) antibody (Cell Signaling, cat. no. 3018). An anti-actin (20–33) antibody (Sigma-Aldrich, cat. no. A5060) was used as a loading control. 4.3.

(6) mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switchingCell reportsAugust 29, 2023Shin S, Han MJ, Jedrychowski MP, Zhang Z, Shokat KM, Plas DR, Dephoure N, Yoon SO.AB_2238583" Anti-phospho-Y980-IGF1R,Cell Signaling Technology,"4568S, RRID: AB_2122279" Anti-IGF1R,Cell Signaling Technology,"3018, RRID: AB_560943" Anti-phospho-S636/639-IRS1,Cell Signaling Technology,"2388, RRID: AB_330339" Anti-IRS1,Cell Signaling Technology

(7) Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2Communications biologyAugust 19, 2023Potalitsyn P, Mrázková L, Selicharová I, Tencerová M, Ferenčáková M, Chrudinová M, Turnovská T, Brzozowski AM, Marek A, Kaminský J, et al.(Cell Signalling Technology #3025, dilution 1:1000), anti-IGF1R β (111A9) Rabbit mAb (Cell Signaling Technology #3018, dilution 1:1000) and anti-M6P/IGF2R (D3V8C) Rabbit mAb (Cell Signaling Technology #14364, dilution

(8) A neomorphic mutation in the interferon activation domain of IRF4 causes a dominant primary immunodeficiencyThe Journal of experimental medicineJune 5, 2023Thouenon R, Chentout L, Moreno-Corona N, Poggi L, Lombardi EP, Hoareau B, Schmitt Y, Lagresle-Peyrou C, Bustamante J, André I, et al.#50784, donkey anti-rabbit #A21206; Invitrogen, and goat anti-mouse #A11003; Invitrogen). DAPI (#910-3018; Chemometech) and phalloidin (#8940; Cell Signaling) were added for 40 min. After several washes, the

(9) A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiencyScience ImmunologyJanuary 20, 2023IRF4 International Consortium, Oriol Fornes, Alicia Jia, Hye Sun Kuehn, Qing Min, Ulrich Pannicke, Nikolai Schleussner, Romane Thouenon, Zhijia Yu, María de los Angeles Astbury, et al.isothiocyanate, Jackson ImmunoResearch, #50784). 4′,6-diamidino-2-phenylindole (DAPI; Chemometech, #910-3018) and phalloidin (Cell Signaling, #8940) were added for 40 min. After several washes, fluorescence was

(10) PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancerFront Endocrinol (Lausanne)October 18, 2022Jeanesse Scerri, Christian Scerri, Felix SchÃ¤fer-Ruoff, Simon Fink, Markus Templin, Godfrey GrechmAb,150805,456009,861935,-1.60,0.92 IGF1,"IGF1 receptor beta (Insulin receptor beta, CD221)",Cell Signaling,3018,Rb mAb,308,153,166,1.02,0.12 MEK/ERK,MAPKAPK-2,Cell Signaling,12155,Rb mAb,392,556,453,-0.50,-0.29 MEK/ERK,MEK

(11) PLG nanoparticles target fibroblasts and MARCO+ monocytes to reverse multiorgan fibrosisJCI insightMarch 8, 2022Xu D, Bhattacharyya S, Wang W, Ifergan I, Wong MAC, Procissi D, Yeldandi A, Bale S, Marangoni RG, Horbinski C, et al.incubated with Abs to α-SMA (MilliporeSigma) or phospho-Smad2 (Cell Signaling Technology Inc.; catalog 3018) at a 1:100 dilution, followed by Alexa Fluor–labeled secondary Abs (Invitrogen). Nuclei were counterstained

(12) IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAKScientific reportsMay 24, 2021Lehman CE, Spencer A, Hall S, Shaw JJP, Wulfkuhle J, Petricoin EF, Bekiranov S, Jameson MJ, Gioeli D.Paxillin Y118 (Cell signaling, #2541), Paxillin (BD Transduction, #610052), IGF1Ra (Cell signaling, #3018), IGF1R Y1135/Y1136 (Cell signaling, #3024), Actin (Santa Cruz, #sc47778). Proteins were normalized

(13) Procyanidins mediates antineoplastic effects against non-small cell lung cancer via the JAK2/STAT3 pathwayTranslational Cancer ResearchMay 1, 2021Yue Wu, Chi Liu, Yuxu Niu, Jiamin Xia, Liwen Fan, Yun Wu, Wen GaoCell Signaling Technology, Beverley, MA, Transl Cancer Res 2021;10(5):2023-2035 | http://dx.doi.org/10.21037/tcr-20-3018 Wu et al. Procyanidins inhibits NSCLC 2026 USA), anti-E-cadherin (3195S, Cell Signaling Technology, Beverley,

(14) N-cadherin upregulation mediates adaptive radioresistance in glioblastomaThe Journal of clinical investigationMarch 15, 2021Osuka S, Zhu D, Zhang Z, Li C, Stackhouse CT, Sampetrean O, Olson JJ, Gillespie GY, Saya H, Willey CD, et al.Slug (1:500, Cell Signaling, #9585), Zeb1 (1:1000, Cell Signaling, #3396), and IGF1R (1:500, Cell Signaling, #3018). Coimmunoprecipitation experiments were performed with a Dynabeads protein A immunoprecipitation kit

(15) CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibitionCell ReportsFebruary 23, 2021Adele M. Musicant et al.overnight at 4°C with primary antibodies: IGF-1 (0.2 μg/mL; Abcam #ab9572), IGF-1Rβ(1:2500; Cell Signaling #3018S), phosphorylated IGF-1Rβ(Tyr1135; 1:1000; Cell Signaling #3918S), PPARγ (1:1000; Abcam #209350), actin

(16) Lin28A/let-7 oncogenic circuit is a potential therapeutic target in neurocutaneous melanosis-associated CNS tumors in childrenNeuro-oncology advancesJanuary 1, 2021Jain M, Tran S, Thakur S, Nagashima Y, Anderson R, Narendran A.Cell Signaling Technology], tumor survival (IGF-1R signaling) [#4568, Phospho-IGF-I Receptor β (Tyr980) (C14A11); #3018, IGF-I Receptor β (111A9), Cell Signaling Technology] and tumorigenic evasion of immune surveillance

(17) Selection of Effective Therapies Using Three-Dimensional in vitro Modeling of ChondrosarcomaFrontiers in Molecular BiosciencesDecember 21, 2020Ieva Palubeckaitė, Sanne Venneker, Inge H. Briaire-de Bruijn, Brendy E. van den Akker, Augustinus D. Krol, Hans Gelderblom, Judith V. M. G. Bovée(1:1600)] (9027S, Cell Signaling, Massachusetts, USA), IGF1R [anti-IGF1R 111A9 rabbit monoclonal (1:2000)] (3018, Cell Signaling), activated caspase-3 [anti-activated caspase-3 rabbit polyclonal (1:1600)] (9661S,

(18) HER2-mediated enhancement of Ebola virus entryPLoS pathogensOctober 1, 2020Kuroda M, Halfmann P, Kawaoka Y.phospho-HER2 (Tyr1248) (2247, Cell signaling technology), MET (3148, Cell signaling technology), IGF-1R (3018, Cell signaling technology), IR (3020, Cell signaling technology), EGFR (4267, Cell signaling technology),

(19) Bayesian Modeling Identifies PLAG1 as a Key Regulator of Proliferation and Survival in Rhabdomyosarcoma CellsMolecular cancer research : MCRMarch 1, 2020Zheng Y, Xu L, Hassan M, Zhou X, Zhou Q, Rakheja D, Skapek SX.(catalog # 9101), p44/p42 MAPK (catalog # 9102), phospho-IGF1R (catalog # 3918) and IGF1R (catalog # 3018), all from Cell Signaling Technology. PLAG1 protein expression in three formalin-fixed, paraffin-embedded

(20) WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancerTheranosticsJanuary 1, 2020Kotrbová A, Ovesná P, Gybel' T, Radaszkiewicz T, Bednaříková M, Hausnerová J, Jandáková E, Minář L, Crha I, Weinberger V, et al.break was not cut. Mutant cell clones were checked by WB using DVL3 antibodies sc-8027 (SCBT) or cs-3018 (CST) and by next generation sequencing using the Illumina platform as described previously 15. DVL3

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IGF-I Receptor beta (111A9) Rabbit mAb

IGF-I Receptor beta (111A9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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IGF-I Receptor beta (111A9) Rabbit mAb from Cell Signaling Technology

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