Fig 1: LENOX and RAP2 modulate oxidative phosphorylation. A, Co-imaging of LENOX, p32, and RAP2 in 501Mel cells transfected with the indicated GapmeRs. B, RAP2-p32 colocalization in a human melanoma FFPE section. C, Levels of 16S rRNA, SAMMSON, and LENOX in mitochondrial and cytoplasmic fractions (top) and levels of RAP2, P32, and HSP60 proteins (bottom) D. Mitostress test of 501Mel cells 48 hours after transfection with indicated GapmeRs or siRAP2C. Experimental groups were compared by one-way ANOVA (Dunnett test). E, Mito Stress Test on cells with ectopic LENOX isoform expression. Experimental groups were compared as in D. *, P < 0.033; **, P < 0.0021; ***, P < 0.0002.