The CLIP3 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CLIP3. This antibody recognizes Human, Mouse, and Rat antigen. The CLIP3 Antibody has been shown to work in the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes.
Subunit Structure: Homodimer. Interacts with AKT1 and AKT2; when AKT1 and AKT2 are phosphorylated and activated, affinity is higher for AKT2 (PubMed:19139280). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635, PubMed:28882895).
Post-translational Modifications: Palmitoylation by ZDHHC17 regulates association with the plasma membrane.
Similarity: Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD)