The APPL1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to appl1. This antibody recognizes Human, and Mouse antigen. The APPL1 Antibody has been shown to work in the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.
Subunit Structure: Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Interacts with OCRL and INPP5B. Interacts with NTRK2 (By similarity).
Post-translational Modifications: Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.
Similarity: Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essential for binding to OCRL and INPP5B