p14ARF Antibody MBS439839 from MyBioSource.com

Product Specs
Itemp14ARF Antibody
CompanyMyBioSource.com
Price $190.00Supplier Page View Company Product Page
Catalog NumberMBS439839
Quantity0.02 mg (With BSA & Azide at 0.2mg/ml)
ApplicationsFlow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ReactivityHuman, Rat. Others not tested
Targetp14ARF
IsotypeIgG2a
Molecular Weight14kDa
Clone4C6/4
HostMouse
ImmunogenThe progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks). Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Multiple proteins are encoded by the tumor suppressor gene CDKN2A (MTS1/ p16INK4a) via translation of alternate reading frames, resulting in the pro- duction of the p19 ARF protein in mice and the p14 ARF protein in humans. p14 ARF induces an increase in MDM2 and p21 levels and leads to cell cycle arrest in both G1 and G2/M. p14 ARF is negatively regulated by p53 and is known to bind directly to MDM2. CDKN2A also encodes the mitotic protein p16, which binds to and inhibits the Cdk4/cyclin D complex
NCBI Full Gene Namecyclin dependent kinase inhibitor 2A
NCBI Gene AliasesP16INK4A, ARF, CDK4I, CDKN2, MTS1, INK4, MTS-1, P16-INK4A, MLM, P14, CMM2, P16, P19, P14ARF, TP16, INK4A, P19ARF, P16INK4
ClonalityMonoclonal