The MADD Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MADD. This antibody recognizes Human, Mouse, and Rat antigen. The MADD Antibody has been shown to work in the following applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Function: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
Subunit Structure: Interacts with the death domain of TNFRSF1A through its own death domain. Interacts with PIDD1.
Similarity: Belongs to the MADD family