MyBioSource.com's CPLX1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The CPLX1 Antibody was generated using Complexin 1, and CPLX1 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Function: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
Subunit Structure: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
Similarity: Belongs to the complexin/synaphin family