MyBioSource.com's CD41 antibody is a Rat monoclonal antibody. It reacts with Mouse. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, and Immunoprecipitation.
Description
The MWReg30 monoclonal antibody reacts with mouse CD41. While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells. Specifically, it was found that CD150+CD48-bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41-as an expression profile efficiently identifies hematopoietic stem cells