The PRDM14 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PR/SET domain 14, and PRDM14. This antibody recognizes Human, Mouse, and Rat antigen. The PRDM14 Antibody has been shown to work in the following applications: ChIP, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Description: This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.
Function: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
Subunit Structure: Interacts with CBFA2T2.
Similarity: The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity. Belongs to the class V-like SAM-binding methyltransferase superfamily