The WNK2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to WNK2. This antibody recognizes Human, and Mouse antigen. The WNK2 Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Subunit Structure: Forms a complex with the phosphorylated form of STK39.
Post-translational Modifications: Autophosphorylated.
Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily