Fig 2: Flow cytometry analyzed MPs counts for cervical lymph nodes (A) and blood samples (B) from wild type control mice, and those exposed to CO without and with JSH-23 or KYC and euthanized 1.5 ?h later. The last two columns in each figure show data from CD36 knock-out (KO) mice exposed only to air (Cont ?= ?control) or to CO. Data are mean ?± ?SE with the number of replicates shown. The * symbol indicates p ?< ?0.05 versus the control, ANOVA. Box plots rather than dots as in Fig. 2 were used to ease the ability to assess the differences among groups.

Fig 3: CD36 knock-out mouse brain homogenate Western blots were performed for air-breathing control mice, those euthanized 1.5 ?h after CO exposure, and 1.5 ?h after intravenous injections of 60,000 cervical lymph node MPs from a wild type mouse exposed to CO (CO-MPs). This is a representative single blot with mean ?± ?SE values shown beneath each band expressed as fold-change from control for replicate studies (n ?= ?6 for each group), as described in the caption for Fig. 3. There were no significant differences between control and post-CO samples.

Fig 4: Flow cytometry analyzed MPs counts for cervical lymph nodes (A) and blood samples (B) from mice injected with 60,000 cervical lymph node MPs and euthanized 1.5 ?h later. Columns show results for wild type naïve mice injected with node MPs from wild type control mice (Cont-MPs), those injected with node MPs isolated from wild type control mice 1.5 ?h after exposure to CO (CO-MPs), those injected with CO-MPs as well as JSH-23, those injected with CO-MPs as well as KYC, and those injected with CO-MPs that were first incubated with IgG to TSP-1. The last column in each figure show data from CD36 knock-out (KO) mice injected with CO-MPs. Data are mean ?± ?SE with the number of replicates shown. The * symbol indicates p ?< ?0.05 versus the control, ANOVA.