The Anti-BubR1 Rabbit Monoclonal Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to BUB1B. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-BubR1 Rabbit Monoclonal Antibody has been shown to work in the following applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression