TLR4 (25) Antibody sc-293072 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemTLR4 (25) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-293072
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P)
Conjugate/TagUnconjugated
FormatPurified
Reactivitymouse, rat, human, canine
Hostmouse
Clone25
Antibody TypePrimary Antibodies
TargetTLR4
IsotypeIgG1
NCBI Gene AliasesRasl2-8, Ran/M1, CD284, ARMD10, Lps, TLR-4, TOLL, Ly87
ClonalityMonoclonal
NCBI Full Gene Nametoll like receptor 4, toll-like receptor 4

Questions and Answers

What species can the TLR4 antibody be used with in experiments?

The TLR4 antibody is reactive with several species, including humans, mice, rats, and canines.

Has the TLR4 antibody been used in any specific experimental applications?

Yes, the TLR4 antibody has been utilized in various applications, including Western blotting, immunofluorescence, immunohistochemistry, and immunoprecipitation, as demonstrated in multiple studies.

Are there any notable findings from studies that have used the TLR4 antibody?

In a study examining the effects of the nonsaponin fraction of Korean Red Ginseng, the TLR4 antibody was used to show that this fraction inhibited TLR4 expression in bone marrow-derived macrophages, leading to reduced cytokine production during peritonitis ().

How has the TLR4 antibody contributed to understanding inflammatory pathways in research?

The TLR4 antibody has been instrumental in studies investigating the TLR4 signaling pathway, such as in research showing that β-carotene modulates the LPS-induced TLR4 signaling pathway, thereby reducing intestinal inflammation ().

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Therapeutic targeting of blood-derived protein infiltration to modulate neuroinflammation in cerebellar ataxiaJournal of NeuroinflammationApril 16, 2026Se Min Park, Seong Soon Kim, Eunji Cho, Gi Beom Lee, Ji Min Lee, Dong Woon Kim, Jong-Heon Kim, Jung-Eun Kim, Gee Euhn Choi, Ho-Won Lee, et al.14–0862-81, Waltham, MA, USA), rabbit anti-toll like receptor 4 (TLR4; Santa Cruz Biotechnology, Cat#: sc‐293072, Dallas, TX, USA), rabbit anti-phospho-c-Jun (p-c-Jun; Cell Signaling Technology, Cat#: CST3270, Beverly,

(2) Hydrogen gas (H2) pretreatment improves lipopolysaccharide-induced acute liver injury in mice by inhibiting NLRP3 inflammasome activation and pyroptosis signalingFrontiers in ImmunologyMarch 20, 2026Xinling Chen, Wenting Suo, Qiuling Li, Yun Chen, Yao Deng, Luyao Xu, Jiaying Dai, Ning Zhang, Jiean Xu, Jinwen Xu, et al."Affinity Biosciences (Changzhou, Jiangsu, China)",Goat Anti-Mouse IgG (H+L) HRP,#S0002,1:3000 TLR4 antibody,#sc-293072,1:2000,"Santa Cruz Biotechnology (Santa Cruz, CA, USA)" "Santa Cruz Biotechnology (Santa Cruz, CA,

(3) Ultrasound-assisted extraction optimization of Fructus Tribuli polysaccharides: How stir-frying processing alters structures and enhances antihypertensive efficacyUltrason SonochemMarch 19, 2026Shuai Wang, Haiping Sun, Xiyu Lv, Jingna Li, Defeng Du, Fei Guo, Chao Zhanganti-rabbit IgG (H + L) (SA00001-2) were purchased from Proteintech Group (Wuhan, China). TLR4 antibody (sc-293072) was purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). MyD88 (AB219413), IκBα (AB32518),

(4) Mechanism of BMSCs Inhibiting Microglia Activation and Neuroinflammatory Response to Alleviate BCP by Regulating TLR4/ NF-κB Signaling PathwayJ Inflamm ResMarch 10, 2026Lihong Wang, Yu Rong, Yunqi Li, Penghui Ren, Hongfang Yang, Yan Liu, Jing Zhang, Ping Wu, Qingping WenThe following antibodies were used: Iba-1 (Abcam, ab178846, 1:1000), TLR4 (Santa Cruz Biotechnology, sc-293072, 1:1000), NF-κB p65 (Bioss, bs-0465R, 1:1000), p-NF-κB p65 (Affinity, AF2006, 1:1000), and GAPDH (HUABIO,

(5) Mechanism of BMSCs Inhibiting Microglia Activation and Neuroinflammatory Response to Alleviate BCP by Regulating TLR4/ NF-κB Signaling PathwayJ Inflamm ResMarch 10, 2026Lihong Wang, Yu Rong, Yunqi Li, Penghui Ren, Hongfang Yang, Yan Liu, Jing Zhang, Ping Wu, Qingping WenThe following antibodies were used: Iba-1 (Abcam, ab178846, 1:1000), TLR4 (Santa Cruz Biotechnology, sc-293072, 1:1000), NF-κB p65 (Bioss, bs-0465R, 1:1000), p-NF-κB p65 (Affinity, AF2006, 1:1000), and GAPDH (HUABIO,

(6) Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesityNeoplasiaMarch 1, 2026Mohamed Gaber, Lauren M. Moulden, Adam S. Wilson, Valerie Payne, Julia Holmes, Kayla Neary, Abigail Peoples, Mary L. Duet, Adam J. Katz, Pierre-Alexandre Vidi, et al.transferred onto nitrocellulose membranes for immunoblotting. Antibodies against TLR4 (Santa Cruz; sc-293072), TLR5 (Santa Cruz; sc-518106), TLR2 (Santa Cruz; sc-21795), NF-κB p65 (Cell Signaling Technology; 8242),

(7) High-dose taurine supplementation exacerbates alcohol-associated liver disease by inducing gut microbiota dysbiosis and bile acid dysregulation in miceeGastroenterologyFebruary 25, 2026Jingdan Pei, Lixian Chen, Rahul Pushparaj, Panpan Huang, Guihua Pan, Chunbao Sun, Xing Gao, Lihua Zhang, Md Manirujjaman, Chiung-Kuei Huang, et al.(Cpt1a) (ab234111, Abcam), fatty acid synthase (Fasn) (ab22759, Abcam) and Toll-like receptor 4 (Tlr4) (sc-293072, Santa Cruz Biotechnology, Dallas, TX, USA). The blots were developed by using ECL Western blotting

(8) The mechanisms by which hypothalamic neuroinflammation induced by neonatal cerebral ischemia–hypoxia leads to decreased thymic function via the HPA axisCell & BioscienceFebruary 23, 2026Gai-Gai Liu, Li-Yan Shuang, Qian Zhang, Guang-Jun Su, Yun Huang, Jin-Hua Xue, Li-Xia Jiang, Cheng Huang, Tao Chen, Zhi-Hua Huang, et al.Santa Cruz) and Histone H3 (4499, CST) in thymus were detected. Additionally, HMGB1 (ab18256, Abcam), TLR4 (sc-293072, Santa Cruz), p-P65-NF-κB (AN371-1, Beyotime), P65-NF-κB (WL01980, Wanleibio), TNF-α (ab6671, Abcam)

(9) N-(p-Coumaroyl) Serotonin Ameliorates LPS-Induced Inflammation in BV2 Microglia via MAPK/NF-κB Inactivation and HO-1/NQO1 UpregulationCurrent Issues in Molecular BiologyFebruary 21, 2026Chang Hyeon Jeon, Soo-Jin Park, Seok Han Yun, Hyun-Jae Jang, Mun-Ock Kim, Jae-Won LeeUSA)",#ADI-KAS-NO001,130,R COX-2,"Santa Cruz Biotech (Dallas, TX, USA)",#sc-376861,70–72,M TLR4,"Santa Cruz Biotech (Dallas, TX, USA)",#sc-293072,95–120,M MyD88,"Santa Cruz Biotech (Dallas, TX, USA)",#sc-74532,33,M p-p38,"Santa Cruz Biotech (Dallas,

(10) Nocardia rubra cell wall skeleton-induced MARCO expression: implications for improved phagocytosis and cytokine secretion in tumor-associated macrophagesFrontiers in ImmunologyFebruary 12, 2026Guiyuan Zhou, Wei Chen, Xiaomin Dong, Qianyu Guo, Xue Bai, Yan Zheng, Lei Zhang, Suxia Shaoanti-CD86 antibody (Proteintech, 68674-2-Ig, 1:5000), mouse anti-TLR4 antibody (Santa Cruz Biotechnology, sc-293072, 1:1000 for western blot and 1:200 for immunohistochemistry), rabbit anti-TLR2 antibody(Abways Technology,

(11) Targeted C3G delivery by engineered milk exosomes for effective therapy in microplastics-induced colitisMaterials Today BioFebruary 1, 2026Yuanjie Wu, Wen Chen, Xiang Ye, Xingkai Hao, Yuhao Wen, Jian Wu, Danyang Li, Lizhou Xu(Shanghai, China). The MAdCAM-1 (F6) antibody (sc-374398), NR1D1 antibody (ab126271), TLR-4 antibody (sc-293072) and COX-2 antibody (sc-19999) were purchased from Santa Cruz Biotechnology Co., Ltd (Dallas, USA).

(12) The novel IDO-1 inhibitor 3-047 combined with icaritin ameliorates neuroinflammation and diabetes-associated cognitive dysfunction with suppression of TLR4/MyD88/NF-κB signalingFrontiers in ImmunologyJanuary 26, 2026Tingmei Mo, Xia Zhuang, Wenxue Zhao, Baohua Wang, Yuting Wang, Wenjie Ji, Dongguang Liu, Guimin Zhang, Ru Yao, Yan Xu, et al.IL-1β (12242), IL-6 (12912) were purchased from Cell Signaling Technology (Danvers, MA, USA). TLR4 (sc-293072) and Bcl-2 (sc-7382) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). 2.2 Animals

(13) Siglec-E deletion alters AT macrophages phenotypes, induces an inflammatory response, and adipogenesis during diet-induced obesityInternational ImmunopharmacologyJanuary 15, 2026Ahmed Rakib, Md Abdullah Al Mamun, Mousumi Mandal, Nelufar Yasmen, Malvin-Ofosu Ofosu-Boateng, Daniel M. Collier, Frank Park, Maxwell A. Gyamfi, Jianxiong Jiang, Udai P. Singhprimary antibodies specific for NF-κB p65 (cat. no. sc-8008, Santa Cruz Biotechnology) or TLR4 (Cat. no. sc-293072, Santa Cruz Biotechnology). The membranes were washed thrice with TBS containing 0.2% Tween 20 (TBST;

(14) Inhalable songorine-integrated lipid nanomedicine for targeted ARDS therapy via repairing endothelial barrier and inactivating NLRP3 inflammasomeActa Pharmaceutica Sinica BJanuary 1, 2026Haiyan Wang, Zhi-Chao Sun, Chunlei Dai, Ran Liao, Ran Lin, Liying Wang, Wenjun Fu, Ruhe Zhang, Danwen Zheng, Zhongde Zhang, et al.bands. The primary antibodies used above were ZO-1 (1:5000, Proteintech), TLR4 (1:500, Santa Cruz, sc-293072, CA, USA), NLRP3 (1:1000, Adipogen), pro-caspase-1/caspase-1 (1:1000, Adipogen), p-NF-κB p65 (1:500,

(15) Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulationGut MicrobesDecember 31, 2025Zixuan Xiang, Xiangyun Li, Xiaoli Wang, Beiying Deng, Haodong He, Miao Xu, Xiaohan Wu, Cheng Tan, Yafei Liu, Baoping Yu, et al.Proteintech, Wuhan, China), Bcl-2 (T40056, AbMART, Shanghai, China), Bax (#50599–2-Ig, Proteintech), TLR4 (sc-293072, Santa Cruz), TLR9 (A14642, Abclonal), HA-tag (#51064–2-AP, Proteintech), Ac-Histone H3-K9 (P37961–16,

(16) Metal-Associated Particulate Matter (PM2.5) Induces Cognitive Dysfunction: Polygonum multiflorum Improves Neuroinflammation and Synaptic FunctionInternational Journal of Molecular SciencesDecember 25, 2025Hye Ji Choi, Hyo Lim Lee, Ho Jin HeoNO.,Concentration,Manufacturer β-Actin,sc-69879,1:1000,"Santa Cruz Biotechnology (Dallas, TX, USA)" "Santa Cruz Biotechnology (Dallas, TX, USA)",TLR4,sc-293072,1:1000 "Santa Cruz Biotechnology (Dallas, TX, USA)",MyD88,sc-74532,1:1000 "Santa Cruz Biotechnology

(17) BGN Secreted by Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression via Activation of TLR4-Mediated Erk and NF-κB Signaling PathwaysInt J Mol SciDecember 13, 2025Hiroki Yokoo, Yu-Ichiro Koma, Naozane Nomura, Rikuya Torigoe, Masaki Omori, Takashi Nakanishi, Shoji Miyako, Takaaki Nakanishi, Takayuki Kodama, Manabu Shigeoka, et al.phosphorylated NF-κB p65 (pNF-κB; #3033, CST), rabbit total NF-κB p65 (tNF-κB; #8242, CST), mouse TLR4 (#sc-293072, Santa Cruz Biotechmology, Dallas, TX, USA), sheep FAP (#AF3715, R&D Systems), rabbit αSMA (#ab5694,

(18) Advanced Glycation End Products Promote PGE2 Production in Ca9-22 Cells via RAGE/TLR4-Mediated PKC-NF-κB PathwayCellsDecember 2, 2025Misae Ono, Natsuko Tanabe, Risa Ichikawa, Keiko Tomita, Soichiro Manaka, Hideaki Seki, Yuri Imai, Mayu Aoki, Yuma Masai, Tadahiro Takayama, et al.Primary antibodies included COX2 (cat#sc-376861, Santa Cruz Biotechnology, Dallas, TX, USA), TLR4 (cat#sc-293072, Santa Cruz Biotechnology), RAGE (cat#sc-365154, Santa Cruz Biotechnology), p-PKC (cat#9375) or PKC

(19) Baicalein alleviates long-term cognitive impairments induced by repeated neonatal sevoflurane exposure via inhibition of cortical microglial TLR4/NF-kB signalingBrain, Behavior, & Immunity - HealthDecember 1, 2025Yingqiao Niu, Qiuting Zeng, Yan Yang, Wenbo Liu, Hui Zhang, Shuyu Chen, Xiaomin Lifollowing primary antibodies: rabbit anti-Iba-1 (1:200, 10904-1-AP, Proteintech), mouse anti-TLR4 (1:50, sc-293072, Santa Cruz), and mouse anti-p-NF-κB p65 (1:50, sc-136548, Santa Cruz). After washing, sections were

(20) Dapagliflozin treatment ameliorates oxidative stress, apoptosis and inflammation in tenofovir-induced nephrotoxicity in ratsScientific ReportsNovember 29, 2025Vitor Antonio dos Santos, Ana Carolina Rocha Viotto, Mariana Moura Nascimento, Desiree Rita Denelle Bernardo, Maria Heloisa Massola Shimizu, Claudia Ramos de Sena, Antonio Carlos Seguro, Rildo Aparecido Volpini, Ana Carolina de Bragança, Daniele CanaleSanta Cruz Biotechnology sc-53643 / sc-33039 Ser311, CA, USA); anti-TLR4 (1:250; Santa Cruz Biotechnology sc-293072, CA, USA); anti-e-NOS (1:500; BD Bioscience 610296, CA, USA). The labeling was visualized with a horseradish

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TLR4 (25) Antibody

TLR4 (25) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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TLR4 (25) Antibody from Santa Cruz Biotechnology, Inc.

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