Human Integrin ß2/CD18 Antibody AF1730 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHuman Integrin ß2/CD18 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $519.00Supplier Page View Company Product Page
Catalog NumberAF1730
Quantity100 ug (also 25 ug)
ApplicationsMigration Assay,Flow Cytometry,Western Blot,Adhesion Blockade,Neutralization,Immunofluorescence,Immunocytochemistry,CyTOF-ready,Functional Assay
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Conjugate/TagUnconjugated
ConcentrationLYOPH
PurityAntigen Affinity-purified
HostGoat
ReactivityHuman
IsotypeIgG
TargetIntegrin beta 2/CD18
Antibody TypePrimary Antibodies
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant human Integrin ß2, Gln23-Asn700, Accession # AAA59490
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameintegrin subunit beta 2
NCBI Gene AliasesCD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Neutrophil expression of CD41/CD61 complex contributes to their adhesiveness in both healthy individuals and heart failure patientsBMC ImmunolAugust 30, 2025Melissa Djouani, Benjamin L. Dumont, Paul-Eduard Neagoe, Louis Villeneuve, Jean-Claude Tardif, Daniel Gagnon, Normand Racine, Michel White, Martin G. SiroisMPC-11; kappa isotype; 2 µg/mL; STEMCELL Technologies), human CD18 blocking Ab (2 µg/mL; Catalog # AF1730; Bio-Techne, Minneapolis, MN, USA) and its control normal goat IgG (2 µg/mL; Catalog # AB-108-C; Bio-Techne),

(2) PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasmsCell reportsAugust 27, 2024Lin LL, Nayak B, Osmulski PA, Wang E, Wang CP, Valente PT, Wang CM, Tan X, Santanam N, Wang TL, et al.anti-integrin β1 (1:200, R&D Systems, Cat# AF1778), goat polyclonal anti-integrin β2 (1:200, R&D Systems, Cat# AF1730), and mouse monoclonal anti-integrin α3 (1:200, R&D Systems, Cat# MAB1345) were used. For integrin β1-,

(3) Leishmania braziliensis enhances monocyte responses to promote anti-tumor activityCell reportsMarch 26, 2024Dos Santos JC, Moreno M, Teufel LU, Chilibroste S, Keating ST, Groh L, Domínguez-Andrés J, Williams DL, Ma Z, Lowman DW, et al.

(4) Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clustersThe Journal of cell biologyJuly 3, 2023Stempels FC, Jiang M, Warner HM, Moser ML, Janssens MH, Maassen S, Nelen IH, de Boer R, Jiemy WF, Knight D, et al.of IST1 (see below) were also probed for integrin β2 (polyclonal goat IgG anti-integrin beta 2/CD18; AF1730; R&D Systems) at 1:1,000. Stimulation using lipopolysaccharide MoDCs, neutrophils, and monocytes were

(5) The metabolism of cells regulates their sensitivity to NK cells depending on p53 statusScientific reportsFebruary 25, 2022Belkahla S, Brualla JM, Fayd'herbe de Maudave A, Falvo P, Allende-Vega N, Constantinides M, Khan AUH, Coenon L, Alexia C, Mitola G, et al.described31. Blocking anti-ULBP1 antibody MAB1380, anti-MICA/B antibody MAB13001 and anti-β2 integrin AF1730 were from R&D systems. NK cell isolation and expansion This work benefited from umbilical cord blood

(6) Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)Scientific reportsJanuary 25, 2022Allende-Vega N, Marco Brualla J, Falvo P, Alexia C, Constantinides M, de Maudave AF, Coenon L, Gitenay D, Mitola G, Massa P, et al.antibodies Metformin was from Santa Cruz Technologies. Fluorescence coupled antibodies against human ICAM-1 (AF1730), ULBP-1 (MAB1380), MICA/B (MAB13001) and the blocking antibody against NKG2D (MAB139) were from R&D Systems

(7) Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4⁺ T Cell Engulfment ProcessCell reportsNovember 5, 2019Davies SP, Reynolds GM, Wilkinson AL, Li X, Rose R, Leekha M, Liu YS, Gandhi R, Buckroyd E, Grove J, et al.AF244), anti-CD44 (Abcam, ab157107), anti-EpCAM (Biolegend, 324201), anti-β2 integrin (Novus Biologicals, AF1730), anti-β1 integrin (Novus Biologicals, MAB17781), Cells were incubated with primary antibody for one

(8) The Extracellular Domain of the β₂ Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic ActivityMBioJuly 9, 2019Ristow LC, Tran V, Schwartz KJ, Pankratz L, Mehle A, Sauer JD, Welch RA.␣L (CR38, 1:500; R&D Systems), ␣M (66519-1, 1:4,000; Proteintech), ␣X (60258-1, 1:4,000; Proteintech), ␤2 (AF1730, 1:1,000; R&D Systems), anti-HlyA polyclonal antibody (1:5,000 [49]), or a pool of anti-HlyA monoclonal

(9) Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesisScience advancesMarch 1, 2019Blatchley MR, Hall F, Wang S, Pruitt HC, Gerecht S.purchased from Santa Cruz Biotechnology (Dallas, TX). ICAM-1 antibody (BBA3), integrin-β2 antibody (AF1730), SDF-1α (350-NS-010), and the Human Protease Proteome Profiler Array Kit (ARY021B) were purchased from

(10) Biomimetic post-capillary venule expansions for leukocyte adhesion studiesScientific reportsJune 19, 2018Benson BL, Li L, Myers JT, Dorand RD, Gurkan UA, Huang AY, Ransohoff RM.(Sigma Aldrich) was used at a final concentration of 100 nanograms per milliliter. Blocking antibodies AF1730 (R&D Systems) and mAb24 (Biolegend) were used at 20 micrograms per milliliter, as were mouse IgG1 isotype

(11) Synthesis of Human Neutrophil Extracellular Traps Contributes to Angiopoietin-Mediated In Vitro Proinflammatory and Proangiogenic ActivitiesJournal of immunology (Baltimore, Md. : 1950)June 1, 2018Lavoie SS, Dumas E, Vulesevic B, Neagoe PE, White M, Sirois MG.

(12) Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particlesEuropean journal of immunologyMay 1, 2018Camilli G, Eren E, Williams DL, Aimanianda V, Meunier E, Quintin J.(16–9922-82, eBioscience) or 10 μg/mL IgG2a Isotype control (16–4724-82, eBioscience); 10 μg/mL anti-CR3 Ab (AF1730, R&D SYSTEM) or 10 μg/mL normal goat IgG control (AB-108-C, R&D SYSTEM); 1–5-10 μM DPI (NADPH oxidase

(13) Bystander cells enhance NK cytotoxic efficiency by reducing search timeScientific reportsMarch 13, 2017Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz EC, Hamed M, Bogeski I, Helms V, Rieger H, Qu B.

(14) An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanismCytokineFebruary 1, 2015Smeekens SP, Gresnigt MS, Becker KL, Cheng SC, Netea SA, Jacobs L, Jansen T, van de Veerdonk FL, Williams DL, Joosten LA, et al.

(15) Mesenchymal stem cell contact promotes CCN1 splicing and transcription in myeloma cellsCell communication and signaling : CCSJune 25, 2014Dotterweich J, Ebert R, Kraus S, Tower RJ, Jakob F, Schütze N.

(16) Identification of the tetraspanin CD82 as a new barrier to xenotransplantationJournal of immunology (Baltimore, Md. : 1950)September 1, 2013Saleh SM, Parhar RS, Al-Hejailan RS, Bakheet RH, Khaleel HS, Khalak HG, Halees AS, Zaidi MZ, Meyer BF, Yung GP, et al.monoclonal anti-human CD82 Ab (Abcam, lot 85961-0) and goat polyclonal anti-human rLFA-1a (R&D Systems, lot AF1730) at 1:50 and 1:500 dilutions, respectively, for 1 h on ice. Cells were washed and treated with donkey

(17) Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activationThe Journal of biological chemistryMarch 4, 2011Jerke U, Rolle S, Dittmar G, Bayat B, Santoso S, Sporbert A, Luft F, Kettritz R.

(18) Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayersDigestive diseases and sciencesOctober 1, 2007van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH.

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Integrin beta 2/CD18 Antibody

Integrin beta 2/CD18 Antibody

Integrin beta 2/CD18 Antibody

Human Integrin ß2/CD18 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (18)

Reviews

Human Integrin ß2/CD18 Antibody from R&D Systems, a Bio-Techne Brand

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