Mouse IL-6R alpha Antibody AF1830 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMouse IL-6R alpha Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberAF1830
Quantity100 ug (also 25 ug)
ApplicationsBioassay,ELISA Development,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,In vivo assay,Neutralization,ELISA Capture (Matched Antibody Pair),Immunocytochemistry,CyTOF-ready
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Conjugate/TagUnconjugated
ConcentrationLYOPH
PurityAntigen Affinity-purified
ReactivityHuman,Mouse,Rat
HostGoat
TargetIL-6R alpha
IsotypeIgG
Antibody TypePrimary Antibodies
NCBI Gene AliasesIL-6R-alpha, CD126, Il6r, IL-6R, IL-6RA
NCBI Full Gene Nameinterleukin 6 receptor, alpha
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse IL-6R alpha, Leu20-Glu357, Accession # P22272
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Endothelial NAD+ depletion drives vascular senescence and neuroinflammation via mtDNA-cGAS/STING-CD38 signaling in Alzheimer's diseaseAlzheimers DementApril 25, 2026Qing-Hua Luo, Fang Li, Li Yang, Han-Qing Pan, Wen-Ping Zhu, Ping Hu, Chu-Ming Tao, Min Yin, Si Zhang, Qiu-Ye Liao, et al.antibody (α‐IL‐6; R&D systems, #MAB406) or anti‐mouse IL‐6Rα blocking antibody (α‐IL‐6R; R&D systems, #AF1830) in CM‐containing medium from bEnd.3 cultures. 2.4 Western blot and VDAC1 expression, oligomerization

(2) A novel modulator of IL-6R prevents inflammation-induced preterm birth and improves newborn outcomeEMBO Molecular MedicineJuly 3, 2025France Côté, Elizabeth Prairie, Estefania Marin Sierra, Christiane Quiniou, Tiffany Habelrih, Wendy Xu, Béatrice Ferri, Xin Hou, Isabelle Lahaie, Nadia Côté, et al.oxidase 4,Proteintech,11242-1-AP Proteintech,Mouse anti-GAPDH,60004-1-Ig Anti-mIL-6R α,R&D systems,AF1830 GAPDH Loading Control Monoclonal Antibody (GA1R),Thermo Fisher Scientific,MA5-15738 Donkey anti-goat IgG-HRP

(3) Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP(3)-Dependent Calcium PathwayMolecular neurobiologyJune 1, 2023Sharma A, Sari E, Lee Y, Patel S, Brenner M, Marambaud P, Wang P.(catalog 662035) were purchased from MilliporeSigma (Burlington, MA). IL-6R neutralizing antibody (catalog AF1830) and normal goat IgG control (AB-108-C) were purchased from R&D Systems, Inc. (Minneapolis, MN). Cell Culture

(4) The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune DacryoadenitisInvestigative ophthalmology & visual scienceApril 3, 2023Singh Kakan S, Li X, Edman MC, Okamoto CT, Hjelm BE, Hamm-Alvarez SF.antibodies—either rabbit anti-gp130/IL-6st (#3732, Cell Signaling Technology) or goat anti-IL-6Rα (AF1830, R&D Systems Minneapolis, MN, USA)—at a 1:1000 dilution at 4°C. After this, membranes were washed three

(5) Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytesCell reports. MedicineNovember 15, 2022Gutierrez AD, Gao Z, Hamidi V, Zhu L, Saint Andre KB, Riggs K, Ruscheinsky M, Wang H, Yu Y, Miller C 3rd, et al.anti-Perilipin from Abcam, ab61682 (1:200); Anti-PDGFRβ from Abcam, ab32570 (1:50); Anti-IL-6R from R&D Systems, AF1830 (1:50). Secondary antibodies (RT, 1 h) were Donkey Alexa 488-conjugated (1:200) and Cy3-conjugated (1:300)

(6) Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated ChemotaxisJournal of immunology (Baltimore, Md. : 1950)August 1, 2021Matsumura F, Polz R, Singh S, Matsumura A, Scheller J, Yamashiro S.unconjugated anti-mouse IL-6Rα (115807, all from Biolegend, San Diego, CA); goat anti-mouse IL-6Rα (AF1830, R&D systems, Minneapolis, MN); normal goat IgG antibody (AB-108-C, R&D systems); rabbit anti-gp130

(7) Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in miceToxicology reportsJanuary 1, 2021Shimada A, Hasegawa-Ishii S.

(8) Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate CancerCancer discoverySeptember 1, 2020Zhao D, Cai L, Lu X, Liang X, Li J, Chen P, Ittmann M, Shang X, Jiang S, Li H, et al.

(9) Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activationJCI insightMarch 12, 2020Zhou M, Aziz M, Denning NL, Yen HT, Ma G, Wang P.MilliporeSigma and Thermo Fisher Scientific. Goat anti-mouse IL-6R polyclonal neutralizing Ab (catalog AF1830) and normal goat IgG (catalog AB-108-C) were purchased from R&D Systems, Bio-Techne. Anti-mouse TLR4/MD2

(10) Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancerEMBO molecular medicineNovember 7, 2019Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid MM, Toombs J, Du W, Wright S, Hagopian M, Wang Z, et al.1:100 for immunofluorescence) antibodies were obtained from Santa Cruz Biotechnology. Anti‐IL‐6Rα (AF1830, dilution 1:1,000 for Western blot) antibody and human IL‐6 neutralizing antibody (MAB2061) were obtained

(11) Role of Proinflammatory Cytokines in Feedback Modulation of Circadian Clock Gene Rhythms by Saturated Fatty AcidsScientific reportsJune 20, 2019Kim SM, Neuendorff N, Earnest DJ.

(12) Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertensionAmerican journal of physiology. Lung cellular and molecular physiologyJune 1, 2019Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA, Espe EKS, Sjaastad I, Løberg EM, Yndestad A, et al.ng/ml, no. 401-ML; R&D systems) for 48 h before IL-6 antibody (mouse IL-6 R ␣-antibody, 1.25 ␮g/ml, no. AF1830, R&D Systems) or an IgG control antibody (rat IgG control antibody, no. 6-001-A, R&D Systems) were added, and

(13) STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infectionThe Journal of experimental medicineApril 2, 2018St Leger AJ, Hansen AM, Karauzum H, Horai R, Yu CR, Laurence A, Mayer-Barber KD, Silver P, Villasmil R, Egwuagu C, et al.

(14) Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130Journal of neuroinflammationJune 23, 2017Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN Jr, Burns ME.from RPE. In the treated groups, 2 μl of polyclonal goat anti-mouse IL6Rα IgG antibody (R&D system, AF1830) or monoclonal rat anti-mouse gp130 IgG1 antibody (R&D system, MAB4682) or monoclonal mouse IgG1 isotype

(15) Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-SignalingScientific reportsMarch 9, 2017Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, et al.Berlin, Germany), and rabbit-anti-meprin β72, mouse-anti-human-IL-6R (4–11)73 and goat-anti-mouse-IL-6R (AF1830, R&D systems, Wiesbaden-Nordenstadt, Germany). Secondary antibodies used were Alexa Fluor 488, biotinylated

(16) Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent mannerImmunity, inflammation and diseaseDecember 1, 2016Owusu-Boaitey N, Bauckman KA, Zhang T, Mysorekar IU.μg/mL, FAC, Sigma–Aldrich, CAS: 1185‐57‐5) and with or without 125 ng/mL anti‐IL‐6Rα (R&D Systems, AF1830) or normal goat IgG isotype control antibody (R&D Systems, AB‐108‐C). Cells were infected with UTI89

(17) Spinal activity of interleukin 6 mediates myelin basic protein-induced allodyniaBrain, behavior, and immunityAugust 1, 2016Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev VI.goat polyclonal IL-6 [R&D Systems (AF506), 1:100], goat polyclonal IL-6 receptor [IL-6R, R&D Systems (AF1830), 1:100], rabbit polyclonal glial fibrillary acidic protein [GFAP, DAKO (Z0334), 1:500], mouse monoclonal

(18) Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritisAnnals of the rheumatic diseasesJuly 1, 2016Nasi S, So A, Combes C, Daudon M, Busso N.527948), PI3 kinase inhibitor Wortmannin (20 mM, Sigma W1628), anti-IL-6 receptor (8 mg/ mL, R&D System AF1830) or Jak2 inhibitor AG490 (50 mM, Calbiochem 658401). Medium was changed for the last 4 days. Fourier transform infrared spectroscopy

(19) Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 ExpressionJournal of immunology (Baltimore, Md. : 1950)January 1, 2016Perez J, Dansou B, Hervé R, Levi C, Tamouza H, Vandermeersch S, Demey-Thomas E, Haymann JP, Zafrani L, Klatzmann D, et al.PA1-16789 (1/500; Thermo Fisher Scientific), anti-gp96 rabbit polyclonal 14491 (1/1000; Abcam), anti–IL-6R AF1830 (1/1000; R&D Systems), anti-gp130 rabbit polyclonal (0.5 mg/ml; Abcam), anti-TLR2 rabbit polyclonal

(20) STAT3 regulated ARF expression suppresses prostate cancer metastasisNature communicationsJuly 22, 2015Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, et al.described67. In brief, microtiter plates (Greiner Microlon) were coated with anti-murine IL-6-R pAB AF1830 (0.8 mg ml 1; R&D Systems) in PBS. After blocking, 100 ml aliquots of cell lysates or culture supernatants

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IL-6R alpha Antibody

IL-6R alpha Antibody

IL-6R alpha Antibody

IL-6R alpha Antibody

IL-6R alpha Antibody

Mouse IL-6R alpha Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Mouse IL-6R alpha Antibody from R&D Systems, a Bio-Techne Brand

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