Axl Antibody from R&D Systems, a Bio-Techne Brand

Yes, the Axl antibody has been utilized in various cancer studies, including its role in triple-negative breast cancer stem cells, where it was shown to be involved in a positive feedback loop with KLF5 that promotes cancer stem cell characteristics (Shen et al., 2022). Additionally, AXL signaling has been implicated in promoting tumor malignancy and immunosuppression in various cancer models (Di Carlo et al., 2023).

The Axl antibody has been successfully used for immunofluorescence applications, as indicated in studies where it was employed to analyze microglial morphology and response during Alzheimer's disease pathogenesis (Huang et al., 2022). It has been recommended for use at a dilution of 1:50 for such applications.

AXL plays a critical role in modulating immune responses during viral infections. For instance, studies have shown that AXL is essential for T cell priming and antiviral immunity, as its absence leads to increased susceptibility to infections like influenza and West Nile virus (Schmid et al., 2016). This suggests that AXL may be a potential target for therapeutic interventions in viral diseases.

The Axl antibody has been used in mouse models to investigate its role in various biological processes, including the response to Zika virus infection. Research indicated that AXL is not an indispensable factor for Zika virus infection in mice, as both Axl-deficient and wild-type mice exhibited similar clinical manifestations and viral loads (Wang et al., 2017). This highlights the complexity of AXL's role in host-pathogen interactions.