LIF Antibody AF-250-NA from R&D Systems, a Bio-Techne Brand

Product Specs
ItemLIF Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $519.00Supplier Page View Company Product Page
Catalog NumberAF-250-NA
ApplicationsImmunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
HostGoat
Conjugate/TagUnconjugated
IsotypeIgG
Quantity100 ug (also 25 ug)
ReactivityHuman,Mouse,Primate - Macaca mulatta (Rhesus Macaque)
TargetLIF
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant human LIF, Ser23-Phe202, Accession # P15018
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human LIF in direct ELISAs.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) EGFR-mutant transformed small cell lung cancer harbors intratumoral heterogeneity targetable with MEK inhibitor combination therapyJCI insightJanuary 23, 2026Ogino A, Vajdi A, Mu XJ, Mahadevan NR, Ngo K, Booker MA, Cejas P, Okoro JJ, Xu M, Springer BF, et al.for mycoplasma as determined the Mycoplasma Plus PCR Primer set (Agilent). LIF neutralizing antibody (AF-250-NA), IL-6 neutralizing antibody (AF-206-NA), and control antibody (AB-108-C) were purchased from R&D Systems.

(2) Factors secreted from the stem cells of human exfoliated deciduous teeth inhibit osteoclastogenesis through the activation of the endogenous antioxidant systemJournal of oral biosciencesMarch 1, 2025Ding C, Hashimoto N, Kano F, Tenshin H, Arai T, Xia L, Xu Y, Lao H, Wang Y, Iwasaki T, et al.

(3) Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylationNature communicationsMarch 18, 2019Kessler M, Hoffmann K, Fritsche K, Brinkmann V, Mollenkopf HJ, Thieck O, Teixeira da Costa AR, Braicu EI, Sehouli J, Mangler M, et al.(1:1000 9145, Cell Signaling), cleaved caspase-3 (1:1000, 9664, Cell Signaling), goat anti-LIF (1:500, AF-250-NA, R&D Systems); secondary - sheep anti-mouse-HRP (1:3000, NA931, Amersham), donkey anti-rabbit-HRP (1:3000,

(4) Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growthOncogeneFebruary 1, 2019McLean K, Tan L, Bolland DE, Coffman LG, Peterson LF, Talpaz M, Neamati N, Buckanovich RJ.anti-IL6 (tocilizumab, Genentech, 10mg/kg, intraperitoneally 3x/week), anti-LIF (human LIF antibody, #AF250-NA, R&D Systems, 4ug, intraperitoneally 3x/week) and ruxolitinib chow (Incyte corporation). Tumor growth

(5) Decreased MUC1 in endometrium is an independent receptivity marker in recurrent implantation failure during implantation windowReproductive biology and endocrinology : RB&EJune 21, 2018Wu F, Chen X, Liu Y, Liang B, Xu H, Li TC, Wang CC.at 4 °C overnight with primary antibody (goat polyclonal anti-human LIF antibody (1:20, R&D system, AF-250-NA), mouse monoclonal anti-human MUC1 antibody (1:50, abcam, ab8949), or rabbit polyclonal anti-human β3

(6) Possible Involvement of Human Mast Cells in the Establishment of Pregnancy via Killer Cell Ig-Like Receptor 2DL4The American journal of pathologyJune 1, 2018Ueshima C, Kataoka TR, Hirata M, Sugimoto A, Iemura Y, Minamiguchi S, Nomura T, Haga H.

(7) Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigoTheranosticsJanuary 1, 2018Yoon JE, Kim Y, Kwon S, Kim M, Kim YH, Kim JH, Park TJ, Kang HY.

(8) Blocking Endogenous Leukemia Inhibitory Factor During Placental Development in Mice Leads to Abnormal Placentation and Pregnancy LossScientific reportsAugust 14, 2015Winship A, Correia J, Krishnan T, Menkhorst E, Cuman C, Zhang JG, Nicola NA, Dimitriadis E.with 0.1% Tween-20 (Bio-Rad) and probed with polyclonal antibody against LIF (1:500; R&D Systems, #AF-250NA) overnight at 4 °C, followed by three wash steps. Membranes were incubated 1 h at room temperature with

(9) Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in MicePloS oneJanuary 1, 2015Winship A, Correia J, Zhang JG, Nicola NA, Dimitriadis E.(TBS) for 30min. Primary antibody for LIFRα (1:100; R&D Systems #AF-249NA), LIF (1:100; R&D Systems #AF250NA), pan-cytokeratin (1:200; Santa Cruz #H-240), α-SMA (1:200; Dako #M085129), F4/80 (1:200; Serotec) or

(10) Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation windowFertility and sterilityJune 1, 2010Xiao Y, Sun X, Yang X, Zhang J, Xue Q, Cai B, Zhou Y.

(11) Disturbances in the LIF pathway in the endometrium among women with unexplained infertilityFertility and sterilityJune 1, 2009Aghajanova L, Altmäe S, Bjuresten K, Hovatta O, Landgren BM, Stavreus-Evers A.

(12) Effect of levonorgestrel and mifepristone on endometrial receptivity markers in a three-dimensional human endometrial cell culture modelFertility and sterilityJanuary 1, 2009Meng CX, Andersson KL, Bentin-Ley U, Gemzell-Danielsson K, Lalitkumar PG.

(13) Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expressionInternational journal of oncologyApril 1, 2007Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H.

(14) Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cellsFertility and sterilityOctober 1, 2006Aghajanova L, Skottman H, Strömberg AM, Inzunza J, Lahesmaa R, Hovatta O.

(15) The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signalingFEBS lettersAugust 15, 2005He W, Gong K, Smith DK, Ip NY.

(16) Tumor necrosis factor, interleukin 11, and leukemia inhibitory factor produced by Langerhans cells in Langerhans cell histiocytosisJournal of pediatric hematology/oncologyNovember 1, 2004Andersson By U, Tani E, Andersson U, Henter JI.

(17) Immunohistochemical localization of leukemia inhibitory factor, interleukins 1 and 6 at the primary implantation site in the rhesus monkeyCytokineDecember 21, 2003Sengupta J, Dhawan L, Ghosh D.

(18) Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cellsThe Journal of clinical endocrinology and metabolismFebruary 1, 2003Ben-Shlomo A, Miklovsky I, Ren SG, Yong WH, Heaney AP, Culler MD, Melmed S.

(19) Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesisCell death & diseaseJanuary 1, 0001"Yue X, Wang J, Chang CY, Liu J, Yang X, Zhou F, Qiu X, Bhatt V, Guo JY, Su X, et al."MedChemExpress. 3H-2-DG was purchased from American Radiolabeled Chemicals. LIF neutralization antibody (AF-250-NA) was purchased from R&D Systems. FDG-PET/CT acquisition and IHC assays De-identified primary breast tumor

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LIF Antibody

LIF Antibody

LIF Antibody

LIF Antibody

LIF Antibody

LIF Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (19)

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LIF Antibody from R&D Systems, a Bio-Techne Brand

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