Mouse TNF-alpha Antibody AB-410-NA from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMouse TNF-alpha Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $519.00Supplier Page View Company Product Page
Catalog NumberAB-410-NA
NCBI Gene AliasesTNFalpha, DIF, Tnfsf1a, TNF-a, Tnfa, TNFSF2, TNF-alpha, Tnlg1f
ApplicationsImmunohistochemistry,Western Blot,In vivo assay,Neutralization,Cell Culture
ReactivityMouse,Rat,Transgenic Mouse
Conjugate/TagUnconjugated
IsotypeIgG
TargetTNF-alpha
HostGoat
Quantity1 mg
NCBI Full Gene Nametumor necrosis factor
ClonalityPolyclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose
ImmunogenE. coli-derived recombinant mouse TNF-alpha, Leu80-Leu235, Accession # P06804
ConcentrationLYOPH
PurityProtein A or G purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Target complement factor H / serum amyloid a signaling in trichloroethylene-induced immune kidney injuryEcotoxicology and environmental safetyJune 15, 2025Xie H, Liang B, Zhao J, You C, Bai Q, Li R, Chen J, Zhou P, Dong L, Cheng R, et al.

(2) N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α SignalingInternational journal of molecular sciencesFebruary 14, 2023Sakai M, Yu Z, Taniguchi M, Picotin R, Oyama N, Stellwagen D, Ono C, Kikuchi Y, Matsui K, Nakanishi M, et al.was confirmed using the goat polyclonal anti-mouse TNF-α antibody (R&D Systems, Minneapolis, MN, USA. AB-410-NA). The secondary antibodies used were Alexa Fluor™ 488-conjugated anti-rabbit IgG (1:300; Invitrogen,

(3) Bi-phasic effect of gelatin in myogenesis and skeletal muscle regenerationDisease models & mechanismsDecember 1, 2021Liu X, Zu E, Chang X, Ma X, Wang Z, Song X, Li X, Yu Q, Kamei KI, Hayashi T, et al.Proteintech (Wuhan, Hubei, China). The monoclonal neutralization Abs against IL-6 (AB-406-NA) and TNFα (AB-410-NA), and recombinant mouse proteins IL-6 and TNFα, were purchased from R&D Systems (Minneapolis, MN, USA).

(4) The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion modelScientific reportsOctober 14, 2020Sato K, Tobo A, Mogi C, Tobo M, Yamane N, Tosaka M, Tomura H, Im DS, Okajima F.MO, USA); Mouse TNF-α ELISA kit (DuoSet), Mouse IL-1β ELISA kit (DuoSet), anti-mouse TNF-α antibody (AB-410-NA), anti-mouse IL-1β (AB-401-NA) antibody, and anti-mouse vascular cell adhesion molecule-1 (VCAM-1, AF643)

(5) Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP MechanismsJournal of the American Society of Nephrology : JASNMay 1, 2020Xu C, Wang L, Zhang Y, Li W, Li J, Wang Y, Meng C, Qin J, Zheng ZH, Lan HY, et al.Treatment Male Mst1/2 dKO mice at 4 weeks of age received an intraperitoneal injection of TNF-a antibody (AB-410-NA; R&D Systems) at a dose of 5 mg/g body wt. Control and other Mst1/2 dKO mice received an injection of

(6) TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in miceScientific reportsJanuary 20, 2020Ono Y, Maejima Y, Saito M, Sakamoto K, Horita S, Shimomura K, Inoue S, Kotani J.DMSO at a final concentration of 0.1% vol/vol. TNF-α neutralizing antibody (goat polyclonal, Cat. No. AB-410-NA; R&D Systems, Minneapolis, MN) was added at 5 μg/mL in PBS at 1 h prior to the addition of LPS. These

(7) Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healingNatureOctober 1, 2019Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prélot L, et al.blocking antibody (R&D systems, AB-406-NA) and goat polyclonal mouse anti-TNF blocking antibody (R&D systems, AB-410-NA). For all experiments, the recombinant cytokines were resuspended according to the manufacturer’s instructions

(8) TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndromeThe Journal of clinical investigationAugust 1, 2018Myles IA, Anderson ED, Earland NJ, Zarember KA, Sastalla I, Williams KW, Gough P, Moore IN, Ganesan S, Fowler CJ, et al.(16). For anti–TNF-α treatment, mice were injected i.p. with 4 mg/kg anti–TNF-α (R&D Systems; catalog AB-410-NA) or goat IgG isotype (R&D Systems) daily for 4 days. The following day, mice were challenged with S.

(9) Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-αPloS oneJanuary 1, 2017Ono Y, Sakamoto K.immediately after the addition of LPS. The anti-TNF-α-neutralizing antibody (goat polyclonal, Cat. No. AB-410NA; R&D Systems, Minneapolis, MN) was added at 5 μg/mL in PBS at 1 h prior to the addition of LPS. The

(10) Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammationScientific reportsFebruary 5, 2016Liu C, Rajapakse AG, Riedo E, Fellay B, Bernhard MC, Montani JP, Yang Z, Ming XF.and control rat IgG1 (16-4301-85) were from eBioscience (Vienna, Austria). Neutralizing anti-TNF-α (AB-410-NA) was from R&D systems (Minneapolis, USA). All reagents for the activity assay of lipogenic enzymes including

(11) Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α, and IL-1βAmerican journal of physiology. Endocrinology and metabolismJuly 15, 2014Zhao Y, Xiao X, Frank SJ, Lin HY, Xia Y.

(12) M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelinationNature neuroscienceSeptember 1, 2013Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, van Wijngaarden P, Wagers AJ, Williams A, Franklin RJM, et al.(BD Biosciences, 610329, 1:100), rat anti-CD16/32 (BD Pharmingen, 553141/2, 1:500), goat anti-TNFα (R & D Systems, AB-410-NA, 1:500), rabbit anti-CD86 (Abcam, ab53004, 1:100), rabbit anti-CCL2 (Biorbyt, orb36895, 1:100), and

(13) TNF-alpha neutralizing antibody blocks thermal sensitivity induced by compound 48/80-provoked mast cell degranulationF1000ResearchAugust 21, 2013Devavani Chatterjea, Luisa Paredes, Tijana Martinov, Evelyn Balsells, Juliann Allen, Akilah Sykes, Alyssa Ashbaughof anti-TNF-α neutralizing antibody (R&D Systems, Minneapolis, MN, Polyclonal Goat IgG, Catalog #: AB-410-NA) or 200μl vehicle was injected intravenously 30 minutes prior to c48/80 injection in a protocol adapted

(14) TNF-alpha neutralizing antibody blocks thermal sensitivity induced by compound 48/80-provoked mast cell degranulationF1000ResearchJanuary 1, 2013Chatterjea D, Paredes L, Martinov T, Balsells E, Allen J, Sykes A, Ashbaugh A.of anti-TNF-α neutralizing antibody (R&D Systems, Minneapolis, MN, Polyclonal Goat IgG, Catalog #: AB-410-NA) or 200μl vehicle was injected intravenously 30 minutes prior to c48/80 injection in a protocol adapted

(15) Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanismMolecular and cellular biologyMay 1, 2012Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, et al.(IL-6), and monocyte chemoattractant protein 1 (MCP-1) were obtained from R&D Systems (catalog no. AB-410-NA, AB406-NA, and AB-479-NA). Cocultured 3T3L1 adipocytes and RAW264.7 macrophages were serum starved for

(16) Ron receptor regulates Kupffer cell-dependent cytokine production and hepatocyte survival following endotoxin exposure in miceHepatology (Baltimore, Md.)May 1, 2011Stuart WD, Kulkarni RM, Gray JK, Vasiliauskas J, Leonis MA, Waltz SE.crystal violet assays and hepatocyte number was calculated based on a standard curve (19). TNFα antibody (AB-410-NA) was from R&D systems. TNFα Hepatocyte Assay Primary hepatocytes were pretreated with 200ng/ml of

(17) Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachmentInvestigative ophthalmology & visual scienceMarch 1, 2011Nakazawa T, Kayama M, Ryu M, Kunikata H, Watanabe R, Yasuda M, Kinugawa J, Vavvas D, Miller JW.Jackson ImmunoResearch Products, West Grove, PA), and the blocking antibody for TNF␣ (1 ␮g/mL, goat IgG, cat. no. AB410-NA; R&D Systems) in mice (8 weeks). Adult primary retinal cultures were prepared as described elsewhere.11 Briefly,

(18) Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alphaJournal of immunology (Baltimore, Md. : 1950)February 1, 2010Hashiramoto A, Yamane T, Tsumiyama K, Yoshida K, Komai K, Yamada H, Yamazaki F, Doi M, Okamura H, Shiozawa S.

(19) Long-lasting neuropathic pain induced by brachial plexus injury in mice: Role triggered by the pro-inflammatory cytokine, tumour necrosis factor alphaNeuropharmacologyApril 1, 2006Quintão NL, Balz D, Santos AR, Campos MM, Calixto JB.

(20) Apolipoprotein E Modulates Clearance of Apoptotic Bodies In Vitro and In Vivo, Resulting in a Systemic Proinflammatory State in Apolipoprotein E-Deficient MiceThe Journal of ImmunologyNovember 15, 2004David J. Grainger, Jill Reckless, Elaine McKilligin␮g/ml; Serotec), anti-fibrinogen (4440-8004, 20 ␮g/ml; Biogenesis; Poole, U.K.), anti-murine TNF-␣ (AB410-NA, 50 ␮g/ml; R&D Systems, Minneapolis, MN), and antiproliferating cell nuclear Ag (M0879, 12 ␮g/ml; DakoCytomation,

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TNF-alpha Antibody

Mouse TNF-alpha Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (21)

Reviews

Mouse TNF-alpha Antibody from R&D Systems, a Bio-Techne Brand

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