LAP (TGF-beta 1) Antibody AB-246-NA from R&D Systems, a Bio-Techne Brand

Product Specs
ItemLAP (TGF-beta 1) Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAB-246-NA
NCBI Gene AliasesTGF-beta1, TGFB, DPD1, TGFbeta, CED, IBDIMDE, LAP
ApplicationsWestern Blot, Immunohistochemistry, Neutralization, Immunocytochemistry
Conjugate/TagUnconjugated
Quantity1 mg
HostGoat
ReactivityHuman
IsotypeIgG
TargetLAP (TGF-beta 1)
NCBI Full Gene Nametransforming growth factor beta 1
ClonalityPolyclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS and NaCl with Trehalose
ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human LAP (TGF-beta 1) and Chinese hamster ovary cell line CHO-derived recombinant human LAP (TGF-beta 1), Leu30-Ser390, Accession # P01137
ConcentrationLYOPH
Brand/TrademarkR&D Systems, a Bio-Techne Brand
PurityProtein A or G purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects human LAP in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody is specific for the LAP derived from the TGF-beta 1 precursor but does not react with LAP from the TGF-beta 2 precursor

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Dupuytren’s Disease Is Mediated by Insufficient TGF-β1 Release and DegradationInternational Journal of Molecular SciencesOctober 11, 2023Lisa Oezel, Marie Wohltmann, Nele Gondorf, Julia Wille, Irmak Güven, Joachim Windolf, Simon Thelen, Carina Jaekel, Vera Grotheerantibodies: 𝛼-SMA (Abcam, Cambridge, UK, ab7817; 1:4000), LAP-TGF-β1 (R&D Systems, Minneapolis, MN, USA, AB-246-NA; 1:1000), LTBP-1 (Thermo Fisher Scientific, Darmstadt, Germany, PA5-45075; 1:1000), Caveolin-1 (Abcam,

(2) TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic nicheJournal of Clinical InvestigationJune 1, 2022Juo-Chin Yao, Karolyn A. Oetjen, Tianjiao Wang, Haoliang Xu, Grazia Abou-Ezzi, Joseph R. Krambs, Salil Uttarwar, Eric J. Duncavage, Daniel C. LinkI (Abcam, ab34710), rabbit anti–collagen III (Abcam, ab7778), goat anti–TGF-β1 (LAP) (R&D Systems, AB-246-NA), PE–anti-CD41 (BD Biosciences, MWReg30), and Alexa Fluor 647–conjugated donkey anti–rabbit IgG (H+L)

(3) Correlation between Fibrillin-1 Degradation and mRNA Downregulation and Myofibroblast Differentiation in Cultured Human Dental Pulp TissueJournal of Histochemistry & CytochemistryJune 1, 2015Nagako Yoshiba, Kunihiko Yoshiba, Naoto Ohkura, Erika Takei, Naoki Edanami, Youhei Oda, Akihiro Hosoya, Hiroaki Nakamura, Takashi OkijiChemicon, Temecula, CA); mouse anti-α-SMA (clone 1A4; A5228; Sigma-Aldrich), goat anti-human TGF-β1 (AB246NA; R&D Systems, Minneapolis, MN), and rabbit anti-human pSmad2/3 (SC11769; Santa Cruz Biotechnology) primary antibodies,

(4) Identification of genetic loci that control mammary tumor susceptibility through the host microenvironmentScientific reportsMarch 9, 2015Zhang P, Lo A, Huang Y, Huang G, Liang G, Mott J, Karpen GH, Blakely EA, Bissell MJ, Barcellos-Hoff MH, et al.TGFβ1 antibody (R&D Systems AF-101-NA, 10) or a polyclonal goat antibody against LAP TGFβ1 (R&D Systems AB-246-NA, 50). Secondary antibodies used were rabbit anti-chicken 568 or 488 and rabbit anti-goat 488 or 568

(5) Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processingInternational journal of cancerJune 15, 2013Wottawa M, Leisering P, Ahlen Mv, Schnelle M, Vogel S, Malz C, Bordoli MR, Camenisch G, Hesse A, Napp J, et al.

(6) Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritisArthritis research & therapyJuly 4, 2012Lauzier A, Charbonneau M, Paquette M, Harper K, Dubois CM.immunoblotted as described [29] by using antiTG2 (ThermoScientific TG100; 1:500), anti-LAP (R&D Systems Ab-246-NA; 1:1,000) or anti-actin (Sigma Ab Statistical analysis The paired or unpaired Student t test or one-way ANOVA

(7) Stromal fibroblast–bone marrow-derived cell interactions: Implications for myofibroblast development in the corneaExperimental Eye ResearchMay 1, 2012V. Singh, V. Agrawal, M.R. Santhiago, S.E. Wilsoninhibitors Polyclonal goat anti-human latency associated peptide (LAP) (TGF-β1) neutralizing antibody (Catalog Number: AB-246-NA) was obtained from R&D Systems, Inc. (Minneapolis, MN) and has been shown to bind mouse LAP (Tsang et

(8) Aclidinium inhibits human lung fibroblast to myofibroblast transitionThoraxMarch 1, 2012Milara J, Serrano A, Peiró T, Gavaldà A, Miralpeix M, Morcillo EJ, Cortijo J.anti-human TGF-β1 monoclonal antibody (4 μg/ml; anti-TGF-β1; R&D Systems, Madrid, Spain; catalogue no. AB-246-NA) was added 30 min before stimulus to block the culture supernatant active form of TGF-β1, as previously

(9) Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus–maternal interfaceREPRODUCTIONFebruary 1, 2010Dana A Massuto, Eric C Kneese, Gregory A Johnson, Robert C Burghardt, R Neil Hooper, Nancy H Ing, Laurie A Jaegerexamined. Immunofluorescence staining Antibodies used for immunofluorescence staining included goat anti-LAP (#AB-246-NA) and chicken anti-TGFB (#AF101-NA) from R&D Systems (Minneapolis, MN, USA); rabbit anti-ITGAV (#AB1930),

(10) Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cellsJournal of cellular biochemistryApril 1, 2006Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW Jr, Chatterjee SK.

(11) Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cellsThe American Journal of PathologyDecember 6, 2002Bo Jian, Jie Xu, Jeanne Connolly, Rashmin C. Savani, Navneet Narula, Bruce Liang, Robert J. LevyCruz Biotechnology (Santa Cruz, CA). Antibody to human latent associated peptide-TGF-␤1 (LAP-TGF-␤1, AB-246-NA) was obtained from R&D Systems (Minneapolis, MN). Antigen was retrieved by heating the slides at 95°C

(12) Role of TGFbeta in development of spontaneous autoimmune thyroiditis in NOD.H-2h4 miceThe Journal of ImmunologyDecember 15, 2001Helen Braley-Mullen, Kemin Chen, Yongzhong Wei, Shiguang Yuof thyroids were stained for latent TGF␤ (35, 36) using anti-human latency-associated peptide (LAP) (AB-246-NA; R&D Systems). After blocking with 1% BSA and 0.3% hydrogen peroxide, slides were incubated overnight

(13) Requirement for Transforming Growth Factor β1 in Controlling T Cell ApoptosisJ. Exp. MedAugust 20, 2001WanJun Chen, Wenwen Jin, Hongsheng Tian, Paula Sicurello, Mark Frank, Jan M. Orenstein, Sharon M. Wahlwith chicken anti–TGF-β (10–20 μg, AB-101-NA; R&D Systems) or with goat anti–human LAP (TGF-β1) (50 μg AB-246-NA; R&D Systems) at 4°C for 30 min. Cells were washed twice with Perm/Wash™ buffer and stained with cyanine

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LAP (TGF-beta 1) Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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LAP (TGF-beta 1) Antibody from R&D Systems, a Bio-Techne Brand

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