Phospho-c-Raf (Ser338) (56A6) Rabbit mAb 9427S from Cell Signaling Technology

Product Specs
ItemPhospho-c-Raf (Ser338) (56A6) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number9427S
Quantity100 µl
ApplicationsW, W-S
ReactivityH, M, R, Mk
Targetc-Raf (Ser338) phosphate
Modificationsc-Raf (Ser338) phosphate
HostRabbit
NCBI Gene AliasesCMD1NN, CRAF, NS5, Raf-1, c-Raf
ClonalityMonoclonal
NCBI Full Gene NameRaf-1 proto-oncogene, serine/threonine kinase
Research AreaMAP Kinase Signaling
IsotypeIgG
Clone56A6
Molecular Weight74

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal CancerJ Cell Mol MedApril 29, 2026Hien Thi My Ong, Eda Ates, Jaeyong Jung, Jeong Soo Sung, Jae-Chul Pyun, Min-Jung Kangglutamate–ammonia ligase (GLUL, #80636), glutamate dehydrogenase (GLUD, #12793), c‐raf (#9422), phospho‐c‐raf (#9427), and E‐cadherin (#3195) were purchased from Cell Signalling Technology (Danvers, MA, USA). For transfection,

(2) A Novel Niclosamide Sulfate Prodrug with Enhanced Bioavailability Suppresses Hepatocellular Carcinoma via Inhibition of Multiple Signaling PathwaysbioRxivApril 18, 2026Mingdian Tan, Steve Schow, Yi Liu, Robert Lum, Dawiyat Massoudi, Renumathy Dhanasekaran, Samuel So, Mei-Sze ChuaRRID: AB_390808, 1:1000 dilution), and phospho-C-Raf (Ser338) (Cell Signaling Technology, cat. no. 9427, RRID: AB_2067317, 1:1000 dilution), and vasorin (Abcam, cat. no. ab156868, 1:500 dilution), PD-L1 (Cell Signaling Technology

(3) N6-methyladenosine–mediated up-regulation of ARRB2 regulates intrahepatic cholangiocarcinoma malignant progression and pemigatinib resistance through MAPK and Hippo signaling pathwaysCell Death & DiseaseApril 15, 2026Haoqi Chen, Xiaowen Wang, Wenfeng Zhu, Wenjie Zheng, Qiwei Yang, Zhixing Liang, Yuan Zhang, Xuejiao Li, Jinliang Liang, Xiaolong Chen, et al.(Cat# 13008, p-YAP), LATS1 (Cat# 3477), Histone-3 (Cat# 9715), c-Raf (Cat# 53745), Phospho-c-Raf (Cat# 9427, p-c-Raf), MEK1/2 (Cat# 8727), Phospho-MEK1/2 (Cat# 9154), ERK1/2 (Cat# 4695), Phospho-MEK1/2 (Cat#

(4) Dectin-1 epigenetic reprogramming rescues senescent-like Treg function in allergic asthmaLife Sci AllianceMarch 17, 2026Xiangdong Sun, Jiaqi Duan, Le Liu, Yanyu Ye, Yang Mi, Pengyuan Zheng, Pingchang Yang, Liguo LiGW5074 was verified by Western blot (detecting phosphorylated Raf-1; anti-p-Raf-1 antibody, clone: 9427; Cell Signaling Technology), and ROS levels were measured using a DCFH-DA ROS detection kit (KeyGen

(5) Proteomics- and BRET- screens identify SPRY2 as a Ras effector that impacts its membrane organizationiScienceDecember 19, 2025Pavic K, Hood FE, Duval CJ, Manoharan GB, Laurini C, Siddiqui FA, Mo SPL, Prior IA, Abankwa DK.,Cell Signaling Technology,9422; RRID: AB_390808 Rabbit monoclonal anti-phospho-C-Raf (Ser338) (56A6),Cell Signaling Technology,9427; RRID: AB_2067317 Rabbit monoclonal anti-p44/42 MAPK (Erk1/2) (137F5),Cell Signaling Technology,4695;

(6) Reversibly unlocking the blood–brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxideActa Pharmaceutica Sinica BDecember 15, 2025Junrong Wu, Guangman Cui, Zhousheng Lin, Wanmei Lin, Yaqing Zhang, Tianhang Zhou, Ping He, Yunjiao Zhang, Guangyu Yao(Cell Signaling Technology 4191, MA, USA), stathmin (Proteintech 11157-1-AP, IL, USA), p-c-Raf (Cell Signaling Technology 9427, MA, USA), c-Raf (Cell Signaling Technology 9422, MA, USA), p-MEK1/2 (Cell Signaling Technology 9121,

(7) STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinomaInt J Mol MedDecember 4, 2025Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying XieProteintech Group, Inc.), RAF1 (cat. no. 26863-1-AP; Proteintech Group, Inc.), phosphorylated (p)-RAF1 (cat. no. 9427; Cell Signaling Technology, Inc.), MEK1/2 (cat. no. 11049-1-AP; Proteintech Group, Inc.), p-MEK1/2 (cat.

(8) NY-ESO-1 facilitates anoikis resistance and tumor metastasis by hijacking deubiquitinase OTUB1 to stabilize PP1αCell Death DisOctober 6, 2025Pengchao Zhang, Jian Cheng, Zhao Liu, Funmilayo O. Adeshakin, Liujiang Dai, Xiangyun Niu, Ziyang Zhang, Xixia Peng, Long Li, Maoxuan Liu, et al.MA); Phospho-ERK1/2 (4370, CST); Phospho-MEK1/2 (9121, CST); Phospho-B-Raf (2696, CST); Phospho-C-Raf (9427, CST); DUSP2 (27327-1-AP, Proteintech); MEK1/2 (9122, CST); K48-linkage specific polyubiquitin antibody

(9) Histone demethylase LSD1 regulates lipid homeostasis during Cryptococcus neoformans infectioniScienceSeptember 19, 2025Gaurav Kumar Lohia, Awantika Shah, Kithiganahalli Narayanaswamy Balaji3291; RRID:AB_2300530 Rabbit monoclonal Anti-Phospho-c-Raf (Ser338),Cell Signaling Technology,Cat# 9427; RRID:AB_2067317 Rabbit polyclonal Anti-SQSTM1/p62,Cell Signaling Technology,Cat# 5114; RRID:AB_10624872 Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L

(10) Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulationNature CommunicationsSeptember 1, 2025Dong Man Jang, Kayla Boxer, Byung Hak Ha, Emre Tkacik, Talya Levitz, Shaun Rawson, Rebecca J. Metivier, Anna Schmoker, Hyesung Jeon, Michael J. Eckwestern blotting with phosphospecific antibodies directed against pSer338 (Cell Signaling Technology, #9427) and pTyr341 (Abcam, #ab59223) (upper panels) and against total CRAF as a loading control (lower panels).

(11) Nav1.6 drives colorectal cancer proliferation and invasion through MAPK signaling pathwayWorld J Gastrointest OncolJuly 15, 2025Li-Ming Zhao, Wan-Ying Hong, Jian-Guang Xu, Shui-Quan Lin, Ming-Sheng Liu, Li-Hui Wang, Xu-Li Jiang, Ming Sang, Yang-Bo Lvagainst Nav1.6 (Abcam ab65166), MAP3K10 (Bioworld BS61034), phospho-c-Raf (Cell Signaling Technology 9427), ERK1/2 (Abcam ab184699), MEK1/2 (Abcam ab178876), Raf1 (Abcam ab137435), MEK1/2 (phospho-S221) (Abcam

(12) Multi-selective RAS(ON) Inhibition Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 and BCL2 Inhibitors in Acute Myeloid LeukemiabioRxivJune 17, 2025Bogdan Popescu, Matthew F. Jones, Madison Piao, Elaine Tran, Andrew Koh, Isabelle Lomeli, Cheryl A.C. Peretz, Natalia Murad, Sydney Abelson, Carolina Morales, et al.#9107), antiphoshpo-Erk1/2 (Thr202/Tyr204, #9101), anti-cRAF (#9422), anti-phospho-cRAF (Ser338, 56A6, #9427), anti-MEK (61B12, #2352), anti-phosphoMEK1/2 (Ser217/221, #9121), anti-RSK1/RSK2/RSK3 (32D7, #9355),

(13) KSR1 Mediates Small Cell Lung Carcinoma Tumor Initiation and Cisplatin ResistanceMolecular Cancer ResearchJune 3, 2025Deepan Chatterjee, Robert A. Svoboda, Dianna H. Huisman, Benjamin J. Drapkin, Heidi M. Vieira, Chaitra Rao, James W. Askew, Kurt W. Fisher, Robert E. Lewisantibody,AB_10861489,Abcam ab109224; 1:1000 dilution Phospho-c-Raf (Ser338) (56A6) Antibody,AB_2067317,Cell Signaling 9427; 1:500 dilution Anti-c-Raf Antibody,AB_390808,Cell Signaling 9422; 1:1000 dilution Phospho-MEK1/2 (Ser217/221) Antibody

(14) KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistanceMol Cancer ResJune 3, 2025Deepan Chatterjee, Robert A. Svoboda, Dianna H. Huisman, Benjamin J Drapkin, Heidi M. Vieira, Chaitra Rao, James W. Askew, Kurt W. Fisher, Robert E. Lewisantibody,AB_10861489,Abcam ab109224; 1:1000 dilution Phospho-c-Raf (Ser338) (56A6) Antibody,AB_2067317,Cell Signaling 9427; 1:500 dilution Anti-c-Raf Antibody,AB_390808,Cell Signaling 9422; 1:1000 dilution Phospho-MEK1/2 (Ser217/221) Antibody

(15) PSAT1 regulated by STAT4 enhances the proliferation, invasion and migration of ovarian cancer cells via the PI3K/AKT pathwayInt J Mol MedApril 7, 2025Xiao Li, Shuang Wang, Xin Nie, Yuexin Hu, Ouxuan Liu, Yuxuan Wang, Bei Lin[including phosphorylated (p-)serine-threonine protein kinases (C-RAF) (Cell Signaling Technology, #9427, 1:100), p-AKT (Cell Signaling, #4060 1:200). Tissue sections were immersed in xylene, followed by dehydration

(16) Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteinsOncogeneMarch 31, 2025Isabel Fernández-Pisonero, L. Francisco Lorenzo-Martín, Mattias Drosten, Eugenio Santos, Mariano Barbacid, Balbino Alarcón, Xosé R. Bustelo(phospho-Ser380, cat. no. 11989, Cell Signaling Technology, 1:1000 dilution), p-c-RAF (phospho-Ser388, cat. no. 9427, Cell Signaling Technology, 1:1000 dilution), and R-RAS (cat. no. sc-523, Santa Cruz Biotechnology,

(17) RAF1 promotes successful human cytomegalovirus replication and is regulated by AMPK-mediated phosphorylation during infectionJournal of VirologyMarch 18, 2025Diana M. Dunn, Ludia J. Pack, Joshua C. Mungernumber GAPDH (D16H11),Cell Signaling Technology,5174 Phospho-Raf1 (c-Raf) (Ser338),Cell Signaling Technology,9427 Phospho-Raf1 (S621),Abcam,ab4767 Phospho-Raf1 (c-Raf) (Ser621),Thermo Fisher Scientific,44–504G Raf1

(18) Pancreatic cancer-derived extracellular vesicles remodel the tumor microenvironment and enhance chemoresistance by delivering KRASG12D protein to cancer-associated fibroblastsMolecular TherapyMarch 5, 2025Xinyuan Liu, Jiaqi Yang, Sicong Huang, Yifan Hong, Yupeng Zhu, Jianing Wang, Yi Wang, Tingbo Liang, Xueli Baiphospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (4370, Cell Signaling Technology), phospho-c-Raf (Ser338) (9427, Cell Signaling Technology), RAF1 monoclonal antibody (66592-1-Ig, Proteintech, Wuhan, China), Akt Antibody

(19) Elevated neuregulin‑1 expression modulates tumor malignancy and autophagy in esophageal squamous cell carcinomaInternational Journal of Molecular MedicineFebruary 12, 2025Yen-Chiang Tseng, Pei-Feng Liu, Yu-Ru Chen, Wen-Hsin Yang, Chia-Che Chang, Hsueh-Wei Chang, Cheng-Hsin Lee, Yih-Gang Goan, Chih-Wen Shu(cat. no. 4060), AKT (cat. no. 4691), p-cellular rapidly accelerated fibrosarcoma (p-cRAF; cat. no. 9427), cRAF (cat. no. 53745), β-actin (cat. no. 3700; all Cell Signaling Technology, Inc.), LC3B (cat. no.

(20) The antipsychotic drug pimozide promotes apoptosis through the RAF/ERK pathway and enhances autophagy in breast cancer cellsCancer Biology & TherapyDecember 31, 2024Ge Jiang, Xingzhi Zhou, Ye Hu, Xiaoyu Tan, Dan Wang, Lina Yang, Qinggao Zhang, Shuangping LiuBcl-xl, and Hippo signaling antibody sampler kit were purchased from Cell Signaling Technology (9102, 9427, D8I9E, 54H6, 8579). Antibodies against mTOR, phospho-mTOR (phospho S2448), LC3B, and SQSTM1/p62 were

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Phospho-c-Raf (Ser338) (56A6) Rabbit mAb

Phospho-c-Raf (Ser338) (56A6) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-c-Raf (Ser338) (56A6) Rabbit mAb from Cell Signaling Technology

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