Lgr5/GPR49 Antibody

Product Specs
ItemLgr5/GPR49 Antibody - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $459.00Supplier Page View Company Product Page
Catalog NumberNLS1236
Quantity0.05 ml
ApplicationsIF/IHC,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunofluorescence
Concentration1.0 mg/ml
Conjugate/TagUnconjugated
FormatPBS and 10% Glycerol
PurityImmunogen affinity purified
ReactivityHuman,Mouse,Rat
TargetLgr5/GPR49
HostRabbit
IsotypeIgG
Antibody TypePrimary Antibodies
ImmunogenA 20 aa synthetic peptide from 1st cytoplasmic domain of human Lgr5/GPR49
ClonalityPolyclonal
Research AreaGPCR, Neuroscience
StorageKeep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles
NCBI Full Gene Nameleucine rich repeat containing G protein-coupled receptor 5
NCBI Gene AliasesFEX, GPR49, GPR67, GRP49, HG38

Specifications/Features

Available conjugates: Unconjugated

Questions and Answers

Can this antibody be used for studying LGR5 in rat models?

Yes, the Lgr5/GPR49 Antibody has been shown to react with rat samples, making it suitable for studies involving LGR5 in rat models.

What applications has this antibody been successfully used in according to the literature?

The Lgr5/GPR49 Antibody has been utilized in immunofluorescence and immunohistochemistry, as indicated by its use in a study examining the transdifferentiation of hepatocytes into biliary epithelial cells during biliary injury in rats ().

Is there any specific concentration recommended for using this antibody in immunohistochemistry?

The antibody has been cited in the literature at a dilution of 1:1000 for immunohistochemistry, which may serve as a guideline for optimal usage in similar applications.

What is the significance of LGR5 in stem cell research, and how might this antibody contribute to that field?

LGR5 is a marker associated with cancer stem cells and plays a crucial role in stem cell biology. The Lgr5/GPR49 Antibody can be instrumental in identifying and characterizing LGR5-positive cells in various contexts, including studies on cell differentiation and regeneration, as demonstrated in research on biliary regeneration ().

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular strokeBrain, behavior, and immunityJanuary 1, 2023Mani KK, El-Hakim Y, Branyan TE, Samiya N, Pandey S, Grimaldo MT, Habbal A, Wertz A, Sohrabji F.room temperature with primary antibodies (Lgr5+ (anti-rabbit)- 1:500ul, Novus Biological sciences, NLS1236; NaK-ATPase-alpha (anti-mouse)- 1: 500ul, Millipore, 05–369–25UG; Villin (anti-mouse)-1:250ul, Santa Cruz

(2) Early appearance of key transcription factors influence the spatiotemporal development of the human inner earCell and tissue researchMarch 1, 2020Johnson Chacko L, Sergi C, Eberharter T, Dudas J, Rask-Andersen H, Hoermann R, Fritsch H, Fischer N, Glueckert R, Schrott-Fischer A.

(3) Immunohistochemistry in Investigative and Toxicologic PathologyToxicologic pathologyJuly 1, 2018Janardhan KS, Jensen H, Clayton NP, Herbert RA.-hepatocellular carcinoma" GPR30,Abcam,ab118512,Rat uterus & cervix LC3,MBL international,M152-3,Mouse colon LGR5,Novus Bio,NLS1236,Mouse intestine MHC II,Abd Serotec,MCA46R,Rat spleen and uterus Muc2,Santa Cruz Biotechnology,sc15334,Mouse

(4) Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary InjuryPloS oneJanuary 1, 2015Chen YH, Chen HL, Chien CS, Wu SH, Ho YT, Yu CH, Chang MH.,Santa Cruz,SC-22840,1:200 HNF-4α,Santa Cruz,SC-6556,1:50 Laminin,Dako Cytomation,Z0097,1:1000 Lgr5,Novus Biologicals USA,NLS1236,1:200 OV6,R&D systems,MAB2020,1:1000 Sox9,Sigma,HPA001758,1:350 Vimentin,Santa Cruz,SC-6260,1:200 Primary

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