ATF-6α (F-7) Antibody sc-166659 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemATF-6α (F-7) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-166659
Antibody TypePrimary Antibodies
NCBI Gene AliasesESTM49, Atf6alpha, ACHM7, ATF6A, 9130025P16Rik, 9630036G24
Quantity200 µg/ml
CloneF-7
Hostmouse
FormatPurified
Reactivitymouse, rat, human
ApplicationsWB, IP, IF, IHC(P), ELISA
Conjugate/TagUnconjugated
ClonalityMonoclonal
NCBI Full Gene Nameactivating transcription factor 6
TargetATF-6
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial InfarctionActa Physiol (Oxf)April 25, 2026María Cuesta-Corral, Alejandro Montoro-Garrido, Ana Romero-Miranda, Fabián Islas, Bunty Ramchandani, Ricardo Gredilla, Joaquín Fernández-Irigoyen, Enrique Santamaría, Beatriz Delgado-Valero, Sara Jiménez-González, et al.dilution 1:1000), activating transcription factor 6 alpha (ATF6α; Santa Cruz, Dallas, TX, USA; Ref: sc‐166659; dilution 1:250), binding immunoglobulin protein (BiP; BD Biosciences, Madrid, Spain; Ref: 610978; dilution

(2) ATF6 ameliorates renal warm ischemia-reperfusion injury through FHL2 -mediated NF-κb signaling pathwayiScienceApril 17, 2026Xuan Wu, Ji-Hua Shi, Yang Bai, Dong-Jing Yang, Meng-Yao Jia, Dan-Feng Guo, Jia-Kai Zhang, Xiao-Yi Shi, Hua-Peng Zhang, Wen-Zhi Guo, et al.Kit (KT101-01, GZSCBIO, Guangzhou, China). Chromatin was immunoprecipitated with anti-ATF6 (1:500, sc-166659, Santa Cruz Technology, Texas, USA) or rabbit IgG control (KT101-01, GZSCBIO, Guangzhou, China). Precipitated

(3) Shear stress-induced Ca2+ influx triggers endoplasmic reticulum stress and cardiomyocyte apoptosis: implications for mitral regulationBiological ResearchFebruary 8, 2026Wei-Ting Chang, Jun-Ming Su, Fan-E Mo, Jhih-Yuan Shih, Wen-Tai ChiuF1BLOK500P). The samples were analyzed using antibodies against Grp78 (BD, 610978), ATF6 (Santa Cruz, sc166659), p-PERK (Cell Signaling, 3179), PERK (Cell Signaling, 3192), p-IRE1α (Abcam, ab48187), IRE1α (Abcam,

(4) Manifold hepatoprotective actions of α-lipoic acid on metabolic function through redox regulation, inflammatory modulation, and anti-apoptosis after chronic sleep-deprived injuryFrontiers in NutritionJanuary 22, 2026Hung-Ming Chang, Hsing-Chun Lin, Ting-Yi Renn, Yu-Cheng Liu, Kai-Jung Yen, Chih-Kai Liao, Maria A. Tikhonova, Tamara G. Amstislavskaya, Sandeep Kumar Singh, Li-You ChenCOX2 (1:200, Santa Cruz, sc-376861), activating transcription factor 6α (ATF6α) (1:200, Santa Cruz, sc-166659), inositol-requiring enzyme 1α (IRE1α) (1:250, Santa Cruz, sc-390960), protein kinase R-like endoplasmic reticulum

(5) Necrotic Cells Alter IRE1α-XBP1 Signaling and Induce Transcriptional Changes in GlioblastomaInternational Journal of Molecular SciencesJanuary 2, 2026Jiwoo Lim, Seulgi Lee, Ye-Seon Hong, Ji Ha Choi, Ala Jo, Jihee Lee Kang, Tae-Jin Song, Youn-Hee Choipurchased from Cell Signaling Technology (Danvers, MA, USA). Antibodies against IκBα (#sc-371), ATF-6α (#sc-166659), and Bax (#sc-493) were purchased from Santa Cruz Biotechnology (Dallas, TX, USA). Antibodies against

(6) Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survivalNature CommunicationsDecember 26, 2025Yanan Chen, Rejani B. Kunjamma, Karin Lin, Li Kai, Maria Dima, Kody Bruce, Ian Steckler, Young Hyun Che, Jason Chan-Zervas, Jaime Eugenin von Bernhardi, et al.caspase 3 (1:400, #9661S, Cell signaling), BCAS1 (1:1000, #445003, Synaptic Systems), ATF6a (1:50, #sc-166659, Santa Cruz), GRP94 (1:200, #10979-1-AP, Proteintech), Bip (1:100, #sc-166490, Santa Cruz), and TRIB3

(7) SCYL1 deficiency in CALFAN syndrome is associated with ER stress and cell deathDisease Models & MechanismsNovember 1, 2025John Hellicar, Tal Dattner, Tian Sun, Lily Percival, Ruby Chrisp, Andrea Pietrobattista, Tomasz Witkos, Aleksander Mironov, Lina Leghlam, Carolin Jentsch, et al.for WB); rabbit anti-phosphorylated PERK (Invitrogen, PA5-40294; 1:1000 for WB); anti-ATF6 (Santa Cruz, SC-166659; 1:1000 for WB) mouse anti-β-actin conjugated to horseradish peroxidase (anti-β-actin-HRP; Santa Cruz,

(8) The role of 7-dehydrocholesterol in inducing ER stress and apoptosis of head and neck squamous cell carcinomaCancer LettersSeptember 28, 2025Bok-Soon Lee, Yea-In Park, Hengtian Liu, Sang Gyu Kim, Hyo Jeong Kim, Ji-Hye Choi, Si Hyun Rho, Joselyn Padilla, Jin Roh, Hyun Goo Woo, et al.NB1002323SS, 1:1000), ATF-4 (D4B8) (Cell Signaling Technology #11815, 1:1000), ATF-6 alpha (F7) (Santa Cruz sc-166659, 1:1000) were used. Secondary HRP-conjugated antibodies against mouse (Cell Signaling Technology #7076,

(9) Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6Annals of NeurologySeptember 24, 2025Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, et al.(1:40; Invitrogen, cat#: PA5‐46936), and mouse anti‐ATF6alpha (1:500; Santa Cruz Biotechnology, cat#: sc‐166659). Secondary antibody in PBS was applied to tissue for an hour at RT. Secondary antibodies used were

(10) ATF6 Alleviates Endothelial Inflammation Following Extended Hepatectomy Through Inhibition of TRIM10/NF-κB SignalingFASEB JAugust 31, 2025Cheng-Cheng Shi, Dong-Jing Yang, Yang Bai, Binhui Zhou, Yao-Hui Sun, Xiao-Ran Xu, Wen-Zhi Guo, Shui-Jun Zhang, Yinming Liang, Yang Jin, et al.stimulation with LPS, the HUVEC lysates were immunoprecipitated with a ChIP‐grade antibody against ATF6 (sc‐166659, Santa Cruz, Dallas, USA) or an anti‐rabbit IgG (KT101‐01, GZSCBIO, Guangzhou, China) as the negative

(11) Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotranspositionNat CommunJuly 11, 2025Wei Yang, Shaobo Cong, Ruoyao Li, Jennifer Schwarz, Thilo Schulze, Raban A. Gevelhoff, Xinyan Chen, Sara Ullrich, Kristina Falkenstein, Denis Ott, et al.Enrichment Kit protocol (Novus Biologicals, NBP2-29482). Full-length ATF6 (1:1000 dilution, Santa Cruz, sc-166659), NRBP1/2 (1:1000 dilution, Proteintech, 21549-1-AP), and GAPDH (1:10000 dilution, Proteintech, 60004-1-Ig)

(12) AA147 Alleviates Symptoms in a Mouse Model of Multiple Sclerosis by Reducing Oligodendrocyte LossGliaJune 1, 2025Metin Aksu, Kevin Kaschke, Joseph R. Podojil, MingYi Chiang, Ian Steckler, Kody Bruce, Andrew C. Cogswell, Gwen Schulz, Jeffery W. Kelly, R. Luke Wiseman, et al.GFAP (1:200, Millipore, AB5541), Sox 10 (1:50, R&D, AF2864), ATF-6a (1:50, Santa Cruz Biotechnology, sc-166659), Arg1 (1:50, Santa Cruz Biotechnology, sc-166920), CD3 (1:50, Santa Cruz Biotechnology, sc-20047),

(13) Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protectionJournal of Advanced ResearchJune 1, 2025Guangping Lu, Yufeng Tang, Ou Chen, Yuanfang Guo, Mengjie Xiao, Jie Wang, Qingbo Liu, Jiahao Li, Ting Gao, Xiaohui Zhang, et al.Affinity Biosciences), anti-AMPKα (Cat# 2532, Cell Signaling Technology), anti-transcription factors 6 (ATF6, Cat# sc-166659, Santa Cruz), anti-glucose-regulated protein 78 (GRP78, Cat# sc-13539, Santa Cruz), anti-protein kinase

(14) Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activationCell BiosciMarch 15, 2025Hye-Young Seo, Ji Yeon Park, So-Hee Lee, Hye Won Lee, Eugene Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jangfrom Sigma-Aldrich (St. Louis, MO, USA). Antibodies against clusterin (SC6420), CHOP (SC7351), ATF6 (SC166659), CTGF (SC365970) and ASC (SC514414) were purchased from Santa Cruz Biotechnology (Dallas, TX, USA).

(15) Do wolframin, P-glycoprotein, and GRP78/BiP cooperate to alter the response of L1210 cells to endoplasmic reticulum stress or drug sensitivity?Cancer Cell IntFebruary 7, 2025Simona Kurekova, Lucia Pavlikova, Mario Seres, Viera Bohacova, Jana Spaldova, Albert Breier, Zdena Sulovawere from Cell Signaling Technology, Inc (Beverly, MA, USA),mouse monoclonal antibodies against ATF6 (sc-166659) were from Santa Cruz Biotechnology, (Dallas,TX, USA) and tubulin (ab56676) were from Abcam (Boston,

(16) Licochalcone A Induces Uterine Leiomyoma Cell Apoptosis via the ROS-Mediated JNK Activation of the GRP78/NRF2 Pathway In Vitro and In VivoAntioxidants (Basel, Switzerland)January 27, 2025Chien HJ, Hu HM, Tsai SJ, Lin CL, Yang SF, Chen JK, Liu CJ, Hsieh YH.(sc-101759, 1:1000), p38 MAPK (sc-7972, 1:1000), p-ERK (sc-101761, 1:1000), ERK (sc-514302, 1:1000), ATF6 (sc-166659, 1:1000) and β-actin (sc-517582, 1:5000) were purchased from Santa Cruz Biotechnology (Dallas, Texas,

(17) PSMG2 role in tumorigenesis and stemness mediated by protein accumulation, reticulum stress and autophagyInternational journal of biological sciencesJanuary 1, 2025Espinosa-Sánchez A, Blanco-Alcaina E, Carnero A.anti-phospho-β-catenin (1:1000; Cell signaling #9561), anti-ATF-6α (1:1000; Santa Cruz Biotechnologies, sc-166659), anti-ATF4 (1:1000; Santa Cruz Biotechnologies, sc-390063), anti-GRP78 (1:1000; Santa Cruz Biotechnologies,

(18) Splicing control by PHF5A is crucial for melanoma cell survivalCell ProliferationAugust 30, 2024Tina Meißgeier, Melanie Kappelmann‐Fenzl, Sebastian Staebler, Ata Jadid Ahari, Christian Mertes, Julien Gagneur, Lisa Linck‐Paulus, Anja Katrin Bosserhoffin 5% BSA/TBS‐T, Cell Signalling 11815), anti‐ATF6 (from mouse, 1:1000 in 5% NFDM/TBS‐T, Santa Cruz sc‐166659). After three washing steps with TBS‐T, the respective horseradish‐peroxidase‐coupled secondary antibody

(19) Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastomaNPJ precision oncologyJuly 25, 2024Freitag T, Kaps P, Ramtke J, Bertels S, Zunke E, Schneider B, Becker AS, Koczan D, Dubinski D, Freiman TM, et al.Alexa Fluor® 647 anti-human ATF4 (Cat# sc-390063, Santa Cruz), Alexa Fluor® 488 anti-human ATF6α (Cat# sc-166659, Santa Cruz), Alexa Fluor® 546 anti-human PERK (Cat# sc-377400, Santa Cruz), and Alexa Fluor® 647 anti-human

(20) Triphenylphosphonium-Conjugated Palmitic Acid for Mitochondrial Targeting of Pancreatic Cancer Cells: Proteomic and Molecular EvidenceInternational journal of molecular sciencesJune 20, 2024Siragusa G, Brandi J, Rawling T, Murray M, Cecconi D.primary antibodies anti-PERK (sc-377400), anti-eIF2α (sc-133132), anti-CHOP (sc-7351), anti-ATF6α (sc-166659), and anti-ATG7 (sc-376212), as well as the secondary antibodies anti-mouse IgG-HRP (sc-516102) and

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ATF-6α (F-7) Antibody

ATF-6α (F-7) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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ATF-6α (F-7) Antibody from Santa Cruz Biotechnology, Inc.

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