MyBioSource.com's PLEK Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The PLEK Antibody was generated using Pleckstrin, and PLEK as the antigen and it reacts with Human.
Description
Pleckstrin is highly expressed in human neutrophils. Pleckstrin is rapidly phosphorylated following treatment of neutrophils in response to inflammatory stimuli, probably by nonconventional PKC isoformsdelta or zeta, which are expressed in human neutrophils. Phosphorylation by nonconventional PKC isoformsinduces a conformational change in pleckstrin that promotes its interaction with membranes and/or with the cytoskeleton, serving to target proteins or lipids recognized by PH domains to sites where they can contribute to the microbicidal response