The Rabbit Anti-Insulin-Like Growth Factor I Receptor Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to IGF1R. This antibody recognizes Human, and Mouse antigen. The Rabbit Anti-Insulin-Like Growth Factor I Receptor Antibody has been shown to work in the following applications: Western Blot.
Description
Type I insulin-like growth factor receptor IGF-IR), a transmembrane tyrosine kinase, is widely expressed among many cell types in fetal and postnatal tissues, as well as many cell lines (1-3). Upon binding of its ligands, IGF-I and IGF-II, autophosphorylation of receptors occurs. The triple tyrosine cluster (Tyr1131, Tyr1135 and Tyr1136) within the kinase domain is the earliest major site of autophosphorylation (4). Phosphorylation of these three tyrosine residues is necessary