MyBioSource.com's Rabbit Anti-Protein Kinase C, theta Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The Rabbit Anti-Protein Kinase C, theta Antibody was generated using prkcq as the antigen and it reacts with Human, Mouse, and Rat.
Description
Protein Kinase Ct (PKCt) is an 80kD member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and homeostasis. Transgenic mice over-expressing dominant negative PKCt develop hyperinsulinimia. PKCt is involved in JNK activation and also plays a specialized role in TCRmediated activation of T and B cells. The activation of PKCt in T cells is associated with its recruitment to the membrane and is mediated by PI3-kinase and Vav. PKCt is a constitutively competent kinase and is auto-phosphorylated on serine 676 in the turn loop and serine 695 in the hydrophobic loop. The phosphorylation on serine 695 contributes to the catalytic activity of PKCt