Fig 1: T cells exhibit an IFN-I response in the nephritic kidney in the cGN model.UMAP plots showing different cell types: CD45+ cells (a) and CD45- cells (b) from the nephritic kidneys, and CD45+ cells from the spleen (c) and blood (d). Ifnb1 expression is also shown. Cells were analyzed 10 days after cGN induction. e IRF7 expression in CD8+ and CD4+ T cells analyzed with flow cytometry. T cells were isolated from the kidney, blood, and spleen 10 days after cGN induction (kidney and spleen, n = 5; blood, n = 4). P values were calculated using one-way ANOVA with Tukey’s multiple comparison test. Data are mean + S.E.M. f Time-course plot showing GzmB expression in CD8+ and CD4+ T cells isolated from the kidney, blood, and spleen on days 0, 3, 10, and 20 (days 0, 3, 20, n = 5; day 10, n = 4). Data are mean ± S.D. Cell type abbreviations: Macro macrophage, DC dendritic cell, NK natural killer, NKT natural killer T, gdT γδ T, PT proximal tubule, TAL thick ascending limb, DCT distal convoluted tubule, CD collecting duct, Endo endothelial cell, Fibro fibroblast. Source data are provided as a Source Data file.