Description
BKS-db-eNOS KO is a double-mutant mouse carrying both a leptin receptor mutation and Nos3 knockout on the BKS background. The model develops obesity, severe type 2 diabetes, systemic hypertension, and early-onset diabetic nephropathy characterized by elevated UACR, glomerulosclerosis, tubular injury, and renal fibrosis. It has been validated with semaglutide and lisinopril and is suitable for studies of diabetes, hypertension, diabetic nephropathy, and therapeutic evaluation