ImageXpress® Pico Automated Cell Imaging System from Molecular Devices

Product Specs
ItemImageXpress® Pico Automated Cell Imaging System
CompanyMolecular Devices
Price Get Pricing Get Quote for this Product
Catalog NumberImageXpress Pico system
QuantityEA
Validated ApplicationsLive cell imaging, Fluorescence, Time lapse
TypeCell Imaging System, Digital, All-in-one
ApplicationsCellular Imaging, Apoptosis Analysis, Cancer Research, Cardiomyocyte Research, Cell Counting, COVID-19 and Infectious Disease Research, Digital Confocal Imaging, Live Cell Imaging, Neurite Outgrowth / Neurite Tracing, Stem Cell Research
Dimensions(WxDxH) 55.1 x 43.5 x 45.3 cm
Plate FormatsUp to 384-well plates
Weight38 kg
Objectives4X to 63X lenses

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Molecular Devices

3860 N First Street

San Jose, California 95134

United States

Phone: 408-747-1700

Company Profile

Website: www.moleculardevices.com

(1) DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responsesJ Exp MedMay 4, 2026Isabelle K. Vila, Yasmine Messaoud-Nacer, Clara Taffoni, Jane Jardine, Roger J. Eloiflin, Adeline Augereau, Soumyabrata Guha, Moritz Schussler, Pierre Le Hars, Joe McKellar, et al.stained with DAPI. The percentage of infected cells (i.e., GFP-positive cells) was quantified using an ImageXpress Pico (Molecular Devices) with a 4× lens. Values were averaged between technical triplicates. Quantifications

(2) Live attenuated vaccination protects aged chimeric ACE2 mice from severe SARS-CoV-2 pathogenicity in vivoPLoS PathogApril 22, 2026Alina Russ, Vera Viherlehto, Stefanie Brey, Sabine Wittmann, Pascal Irrgang, Natascha Leicht, Arne Cordsmeier, Armin Ensser, Ralf J. Rieker, Carol Geppert, et al.ng/ml) and anti-mouse IgG Alexa488 (Cell Signaling 4408S). [43] Infectivity was quantified using the ImageXpress Pico Automated Cell Imaging System (Molecular Devices). Cell isolation and flow cytometry Immune cells in BAL were collected at the indicated

(3) Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleeniScienceApril 17, 2026Layla Pohl, Thomas R. Wittenborn, Ali Shahrokhtash, Kristian S. Kastberg, Cecilia Fahlquist-Hagert, Lisbeth Jensen, Sofie Andkær Pedersen, Julia Karen Demtröder, Donato Sardella, Alain Pulfer, et al.Germany) for 30 min. The central 50% of each well was imaged using the high-content imaging system ImageXpress Pico (Molecular Devices) with a 20× objective. The cell experiments were repeated independently three times,

(4) Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic MacrophagesFASEB JApril 15, 2026Kentaro Takahashi, Julia Drolet, Jinghua Liu, Jasmine R. Jackson, Madison Babcock, Muthusamy Thiruppathi, Milie Fang, Tyler Paul, Gayathri Ganesh, Yuri Fukasawa, et al.with Hoechst 33258 (Millipore Sigma). Images were obtained using an automated cell imaging system (ImageXpress Pico, Molecular Devices, San Jose, CA, USA), and high‐content imaging analysis was performed to count the

(5) Protein Arginine Methyltransferase Inhibitors Target Multiple Stages of Plasmodium falciparum Parasites In VitroACS Infectious DiseasesApril 10, 2026Daniel Opperman, Tayla Rabie, Marché Maré, Mariska Naude, Mariette van der Watt, Jessica L. Thibaud, Megan Shannon, Nicole Sanders, Judith M. Bolscher, Rianne van der Laak, et al.3SP2 antibody and a streptavidin AF555 conjugate and captured by automated high content imaging using ImageXpress PICO (Molecular Devices). Total gliding trail length was analyzed using MetaXpress software with outputs

(6) Design, Synthesis, and Biological Evaluation of Novel Vinyl Selenone Derivatives as Potent Nrf2 Activators for Atopic DermatitisJournal of Medicinal ChemistryApril 9, 2026Jushin Kim, Yoowon Kim, Byungeun Kim, Elijah Hwejin Lee, Rium Kim, Jiwoo Park, Jaehwan Kim, Yonghan Kim, Sang In Park, Minsik Kang, et al.corresponding differential interference contrast (DIC) images to visualize cell morphology, using an ImageXpress Pico (Molecular Devices). Fluorescence intensity was quantified using ImageJ software (NIH). DNCB-Induced

(7) Chemotherapy Enrichment of ID Family Expression Is Associated with IL-6 Signaling in Ovarian CancerCancers (Basel)April 8, 2026Megan Anne Keene, Darren Lighter, Cassandra Brenner, Ixchel Urbano, Katelyn Shelby, Samuel F. Gilbert, Mikella Robinson, Carrie D. Housedays of incubation, spheroids were stained with Hoechst dye and imaged at 10× magnification using the ImageXpress Pico (Molecular Devices, San Jose, CA, USA) system. Spheroid diameters ranging from 30 to 500 μm for formation

(8) Human antibodies against West Nile and related orthoflavivirusesbioRxivApril 6, 2026Tomás Cervantes Cervantes Rincón, Tereza Frckova, Zaria I. Contejean, Jasmine Cantergiani, Kevin Groen, Benedetta Cena, Simone G. Moro, Filippo Bianchini, Luca Simonelli, David Jarrossay, et al.stained using DAPI at a 1:2000 dilution (Sigma, D9542). Fluorescence images were acquired using the ImageXpress Pico automated imaging system and CellReporterXpress software (Molecular Devices, USA). Selection of antibody-resistant

(9) Dual suppression of stemness and redox adaptation in glioblastoma through filaggrin upregulation by an abiraterone-based HDAC inhibitorJ Biomed SciApril 6, 2026Hoang Yen Tran, Ram Sharma, Hong-Yi Lin, Tzu-Yi Yeh, Chih-Jie Shen, Tsung-I. Hsu, Jing-Ping Liou(Thermo Fisher Scientific) was used to label mitochondrial ROS. Live cell imaging was conducted using ImageXpress® Pico Automated Cell Imaging System (Molecular Devices, San Jose, CA, USA). Cellular ROS detection by flow cytometry employed a CellROX

(10) Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling PathwaysOncology ResearchMarch 23, 2026Denisse A. Gutierrez, Elisa Robles-Escajeda, Jose A. Lopez-Saenz, Robert A. Kirken, Edgar A. Borrego, Ana P. Betancourt, Soumya Nair, Sourav Roy, Armando Varela-Ramirez, Renato J. Aguileraallows the quantification of live and dead cells by using two nuclear dyes and a bioimaging system (ImageXpress Pico, Molecular Devices, San Jose, CA). Hoechst, permeable to all cells, facilitates the quantification of

(11) Inflammatory Mediators Both Directly and Indirectly Promote Microglial ProliferationGliaMarch 19, 2026Brady P. Hammond, Eugene Hahn, Kelly V. Lee, Bradley J. Kerr, Jason R. Plemelparameters with MetaXpress (v6.5; Molecular Devices). We assessed neuron culture purity on a commercial ImageXpress Pico widefield microscope. Excitation was achieved from an LED light source with emission passed through

(12) Acute E-Cigarette Aerosol Condensate Exposure Disrupts the Transcriptome and Proteome Profiles of Human Bronchial Epithelial BEAS-2B CellsCellsMarch 16, 2026Sara Trifunovic, Jelena Kušić-Tišma, Katarina Smiljanić, Aleksandra Divac Rankov, Jelena Dinić, Mila Ljujićmin at 37 °C. Cells were then washed with phosphate-buffered saline (PBS) and visualized using the ImageXpress® Pico Automated Cell Imaging System (Molecular Devices, San Jose, CA, USA) with a 10× objective. The obtained TMRE images were analyzed

(13) Fimepinostat Promotes Apoptosis and Decreases Cytokine Secretion in NF2-Related Human Schwannoma CellsInt J Mol SciMarch 13, 2026Anna Nagel, Ethan W. Hass, Hollie Hayes, Lenna Huelbes, Sofia Oliveira, Haley M. Hardin, Mikhail Marasigan, Eric Nisenbaum, Carly Misztal, Fred F. Telischi, et al.Cells were imaged either using a Keyence BZ-X800 microscope or a Molecular Devices (San Jose, CA, USA) ImageXpress Pico microscope, capturing two to four regions of interest per replicate. Quantification was performed using

(14) Xiao Chai Hu Tang-derived decoction (Tung-Yi Fang) suppresses triple negative breast cancer cells in vitro and in vivo via regulating EGFR/AXL-mediated signalingFront PharmacolMarch 13, 2026Li-Lan Liao, Zhi-Hu Lin, Chia-Ching Liaw, Hsin Yeh, Wei-Hao Wang, Yun-Chih Chen, Yi-An Lin, Ai-Jung Tseng, Yu-Chun Lin, Wen-Hsin Tsai, et al.using 4′,6-diamidino-2-phenylindole (DAPI; Sigma-Aldrich). Fluorescence images were acquired using an ImageXpress Pico Automated Cell Imaging System (Molecular Devices, United States). Animal model Six-week-old female BALB/c mice were obtained from

(15) mRNA-based CAR T cell engineering: Unmodified mRNA enables high CAR expression without innate immune activation in T cellsMolecular Therapy Nucleic AcidsMarch 12, 2026Nourhan Kahwaji, Niklas Kotzian, Jasmin Melissa Prinz, Yaolin Pu, Jonas Kath, Samira Picht, Anna Luisa Hiller, Antonia Klaas, Charlotte Maeve Dunne, Michael Launspach, et al.1:1, 1:2, and 1:4. The total GFP-positive area was measured every 4 h over a 28-h period using the ImageXpress PICO automated imaging system (Molecular Devices) to assess target cell killing relative to signal at 0 h

(16) Differential targeting of human pyroptotic caspase-5 and caspase-4 by Shigella OspC2 and OspC3mBioMarch 11, 2026Kyungsub Kim, Marcos Antonio Valdespino Diaz, Rowan M. Karr, Michele E. Muscolo, Lisa Goers, Truelian Yu, Tera C. Levin, Jonathan N. Pruneda, Cammie F. LesserHEPES plus gentamicin (50 µg/mL), 3 µM PI, and 16.2 µM Hoechst 33,342. The plate was imaged using an ImageXpressPICO automated microscope (Molecular Devices) using a 20×/0.4 lens with DAPI and Texas Red filters. Images

(17) A stable two-component cationic liposome platform for mRNA delivery induces CD8+ T-cell responses and protection in a murine lymphoma modelJournal of NanobiotechnologyMarch 7, 2026Gabriel Kristian Pedersen, Reham Sabah Alhakeem, Ahmad Tami, Dennis Christensen, Zahra Shabanian, Rune Fledelius Jensen, Katharina Wørzner, Signe Tandrup Schmidtcells were returned to the incubator for 40 h, and the eGFP expression evaluated by imaging on the ImageXpress Pico automated cell imaging system (Molecular Devices, San Jose, CA, USA) and by flow cytometry in the FITC channel on a Cytoflex (Beckman

(18) From Patient Liver Tissue to Organoids: Establishment of a Translational Platform Using Healthy, Steatotic, and Cirrhotic Tissue SourcesCellsFebruary 28, 2026Robert F. Pohlberger, Katharina S. Hardt, Mark P. Kühnel, Julian Palzer, Johanna Luisa Reinhardt, Oliver Beetz, Felix Oldhafer, Franziska A. Meister, Katja S. Just, Sarah K. Schröder-Lange, et al.as 4πr2, where r represents the radius of the organoid manually extracted from time-lapse imaging (ImageXpress Pico, Molecular Devices, San José, CA, USA). The surface was used for comparison with monolayer cultures.

(19) Therapeutic targeting of YOD1 disrupts the PAX-FOXO1-N-Myc feedback loop in rhabdomyosarcomaJCI InsightFebruary 9, 2026Wenwen Ying, Jiayi Yu, Xiaomin Wang, Jiayi Liu, Boyu Deng, Xuejing Shao, Jinhu Wang, Ting Tao, Ji Cao, Qiaojun He, et al.Subsequently, high-throughput imaging of EGFP and DAPI signals from each cell was performed using an ImageXpress Pico scanner (Molecular Devices). The average EGFP intensity was measured to assess protein expression. The

(20) NLRP3 Inflammasome Inhibition by Xuanfei Baidu Decoction Attenuates Pulmonary Inflammation and Collagen Deposition in SilicosisPharmaceuticals (Basel)February 1, 2026Qianru Zhao, Junhong Wang, Ziwei Yan, Tao Liu, Lin Ma, Jing Qian, Yu Wang, Rui Shao(1:500) and a FITC-conjugated secondary antibody (1:200), respectively. The images were recorded by an ImageXpress Pico 7.1.1 (Molecular Devices, San Jose, CA, USA) and analyzed using ImageJ 1.51. For the ASC oligomerization

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