Fig 1: DIZE effect on (A) renal ACE2 (ng/ml) and (B) renal Ang II (pg/mL) in rats of control, MetS, and MetS + DIZE groups. MetS, fructose-induced metabolic syndrome; MetS + DIZE, fructose-induced metabolic syndrome; DIZE treated. Data are expressed as mean ± SD (n = 10). ANOVA was used to make group comparisons. P < 0.05 considered significant **P < 0.001 vs. control group, ##P < 0.001 vs. MetS group.
Fig 2: Comparison of pancreatic tissue levels of local-RAS and alternative components among the study groups. Values are mean ± SD. (a) Renin. (b) Angiotensin-converting enzyme (ACE). (c) Angiotensin II (Ang II). (d) Renin mRNA fold changes. (e) Angiotensin-converting enzyme (ACE2). (f) Angiotensin-(1-7) (Ang-(1-7)). (g) Angiotensinogen mRNA fold changes. (h) Tissue ratio of Ang-(1-7)/Ang II. NC: normal control; DC: diabetic control; HESS: hydroalcoholic extract of S. securidaca seeds. Pvalue = ∗(0.01 − 0.05); ∗∗(0.001-0.01); ∗∗∗(0.0001-0.001); ∗∗∗∗(<0.0001).
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