Fig 1: Effect of flagellin on the production of anti-microbial peptides in CS-exposed mice infected with NTHi.(a) mRNA expression of Defb2, S100A8 and S100A9 in the lungs of control versus CS-exposed mice infected or not with NTHi and treated or not with flagellin. (b) Concentrations of Defb2, S100A8 and S100A9 in the BAL of control versus CS-exposed mice infected or not and treated or not with flagellin. BAL were collected 24h and 48h after infection. Three independent experiments have been performed with at least 3 mice in each group. The data are expressed as mean ± SEM*: p<0.05, **: p<0.01, ***: p<0.001.