Fig 1: Simplified diagram of the lipid metabolism canonical pathway. Maturation of HDL and free cholesterol (FC) esterification are catalyzed by LCAT. Apo A-I and Apo E activate LCAT, and PON-I, which is also activated by Apo A–I, avoiding LCAT inactivation. Apo D binds to LCAT to improve its esterification activity. Finally, cholesterol is transported to the liver for its elimination by fecal excretion.
Fig 2: Impact of the intake of ω3-milk on the high density lipoprotein (HDL) profile. Box-Plots and 2-DE representative images showing the significant changes induced in HDL proteins by ω3-milk: (a) Apo A–I (p = 0.009); (b) lecitin cholesterol acyltransferase (LCAT) (p = 0.044); (c) paraoxonase-1 (PON-1) (p = 0.047); (d) Apo D (p = 0.008); and (e) Apo L1 (p = 0.038).
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