Fig 1: Plasma analysis for young and older adults in the post-absorptive, post-prandial and post-exercise states. Analyses of plasma IP6K1 (A) concentration and (B) area under the curve (AUC) (Protein, P = 0.008; Protein + Exercise, P = 0.001). Plasma glucose (C) Concentration and (D) area under the curve (Protein, P = 0.899; Protein + Exercise, P = 0.738). Plasma insulin E) Concentration and F) area under the curve (Protein, P = 0.359; Protein + Exercise, P = 0.006). (n = 9/group). * P < 0.05 vs older adults protein trial. ** P < 0.05 vs older adults exercise trial + P < 0.05 vs young adult basal. ^ P < 0.05 vs all within group. Data are mean ± SEM.
Fig 2: Skeletal muscle signalling of the IP6K1-IGFR-Akt pathway in young and older adults expressed as fold change from young basal. (A) Skeletal muscle signalling of IP6K1. (B) Skeletal muscle signalling of p-Akt308 and (C) Phosphorylated/total Akt308. (D) Skeletal muscle signalling of p-Akt473 and (E) Phosphorylated/total Akt473. Cropped blot images for proteins of interest at (G) basal (H) post-prandial (-) and post-exercise ( +). (n = 9/group). * P < 0.05 vs basal within group. # P < 0.05 vs 120 min. ^ P < 0.05 vs older adult protein trial. ~ P < 0.05 vs older adult protein + exercise trial. Data are mean ± SEM.
Fig 3: Correlation analysis for young (n = 9) and older (n = 9) adults in the post-absorptive (basal) state for young and older adulats are displayed for (A) HOMAIR & plasma IP6K1 (Young, P = 0.090; Older, P = 0.299), (B) HOMAIR & muscle IP6K1 (Young, P = 0.002; Older, P = 0.042), (C) phenylalanine rate of disappearance (Rd) & plasma IP6K1 (Young, P = 0.895; Older, P = 0.297), (D) age & plasma IP6K1 (Young, P = 0.653; Older, P = 0.444). (E) 120 min Post-exercise phenylalanine rate of disappearance (Rd) & muscle IP6K1 (Young, P = 0.019; Older, P = 0.148). (F) 120 min Post-prandial plasma IP6K1 & muscle IP6K1 (Young, P = 0.062; Older, = 0.496).
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