Fig 1: Hsa_circ_0002348 exacerbated preeclampsia-like symptoms in the mice. A Modeling schema of LPS-induced preeclampsia mice model, and treatment with hsa_circ_0002348 or pZW1 control vector (n = 3/group for each experiment); animal experiments independently repeated in triplicate; B qRT-PCR analysis of hsa_circ_0002348 in the mice’s placentas of each group; systolic BP C, diastolic BP D, and proteinuria level E, observed on GD 5, GD 14 and GD 16 in each group; F representative image of the fetal mice and placenta in the blank control, LPS, LPS+pZW1, and LPS+circ_0002348 group, respectively; ELISA analysis for PIGF detection (G), sFlt-1 H and TNF-a (I) in the plasmas of the pregnant mice of each group; J representative HE and PAS staining of the images in the pregnant mice’s kidneys, and representative HE and MASSON staining of the images in the pregnant mice’s placentas of each group; glomerular endotheliosis and abnormal stromal collagen deposition observed to be evident in the kidney and placental labyrinth layer, respectively; scar bars, 50 µm. circ_0002348 representing hsa_circ_0002348; the data presented as mean ± SEM; *p = 0.05, **p = 0.01, ***p = 0.001, ****p = 0.0001; ns not significant