Description
Complement factor H is a glycoprotein crucial for maintaining a balanced immune response by regulating complement activation. It serves as a soluble inhibitor of complement by binding to self-markers like glycan structures to prevent complement activation and amplification on cell surfaces. In mice, complement factor H primarily regulates the alternative pathway of the complement system, controls inflammatory responses, and contributes to the onset and progression of various diseases. To explore CFH's role in diseases, scientists have created mouse models that mimic the pathophysiological processes associated with human CFH gene mutations