Description
Gamma-enolase exhibits neurotrophic and neuroprotective properties across a wide range of central nervous system (CNS) neurons. It binds to cultured neocortical neurons in a calcium-dependent manner, promoting their survival. Eno2 is expressed in neurons and is linked to various neurodegenerative diseases. For instance, in the Ugt1 knockout mouse model, Eno2 overexpression is associated with neuronal cell death in the brain, potentially related to bilirubin-induced oxidative stress. Additionally, in a mouse model of aneurysm formation, Eno2 influences cell fate by regulating autophagy-related pathways, such as PI3K and MAPK/ERK26