Fig 1: Lactobacillus promotes the suppressive effects of prednisone on Tfh response in EAH mice. A The level of IL-21 in the serum of EAH mice by treatment of prednisone or prednisone + Lactobacillus was assessed by ELISA. B The portion of CD4+CXCR5+ICOS+ Tfh cells in the PBMCs of EAH mice by treatment of prednisone or prednisone + Lactobacillus was detected by flow cytometry analysis. C The mRNA levels of IL-21, Bcl-6, and CXCR5 in the liver of EAH mice by treatment of prednisone or prednisone + Lactobacillus were revealed by RT-qPCR. The data are presented as the mean ± SEM. ***P < 0.001 vs control, #P < 0.05 vs EAH, @P < 0.05 vs EAH + prednisone