Fig 1: The analysis of PAR1 expression in full-thickness human skin equivalents and wound models. (a) Compares PAR1 expression levels between unwounded controls and wound models to highlight PAR1’s role during the wound-healing process. (b) Shows the impact of PM10-PAHs on PAR1 expression in wound models at various concentrations. (c) Presents the effects of PM10-Trace on PAR1 expression, demonstrating its differential influence compared with PM10-PAHs.
Fig 2: Increased blood MCP-1 and cholesterol synthesis in women with CSP. (A) Detection of PAR-1, MCP-1, CCR2, SREBP2, HMGCR and HMGCS concentrations in the blood of three groups of patients. (B) Comparison of blood cholesterol levels in three groups of patients. Data are expressed as the mean ± standard deviation. **P<0.01 and ***P<0.001. MCP-1, monocyte chemoattractant protein-1; CSP, cesarean scar pregnancy; PAR-1, protease-activated receptor-1; CCR2, chemokine (C-C motif) receptor 2; SREBP2, sterol regulatory element-binding protein 2; HMGCR, hydroxy-3-methylglutaryl-CoA reductase; HMGCS, hydroxy-methyl-glutaryl Coenzyme A synthase; NP, normal intrauterine pregnancy without history of cesarean section; NPACS, normal intrauterine pregnancy after cesarean section; ns, not significant (P>0.05).
Fig 3: Increased MCP-1 and cholesterol synthesis in decidual stromal cells localized at the gestational sac of women with CSP. (A) Heat map results of decidual stromal cell chemokine and chemokine receptor extracted from the gestational sac localization of the three groups of patients. (B) Volcano map results of two-by-two comparison of chemokine and chemokine receptor of decidual stromal cells extracted from patients' gestational sac localization. (C) Gene expression of PAR-1, MCP-1 and CCR2 in decidual stromal cells extracted from patients' gestational sac localization in the three groups. (D) Gene expression of SREBP2, HMGCR and HMGCS in decidual stromal cells extracted from patients' gestational sac localization in the three groups. Data are expressed as the mean ± standard deviation. ns, P>0.05 and ***P<0.001. MCP-1, monocyte chemoattractant protein-1; CSP, cesarean scar pregnancy; PAR-1, protease-activated receptor-1; CCR2, chemokine (C-C motif) receptor 2; SREBP2, sterol regulatory element-binding protein 2; HMGCR, hydroxy-3-methylglutaryl-CoA reductase; HMGCS, hydroxy-methyl-glutaryl Coenzyme A synthase; NP, normal intrauterine pregnancy without history of cesarean section; NPACS, normal intrauterine pregnancy after cesarean section; ns, not significant (P>0.05).
Supplier Page from Abcam for Human PAR1/Thrombin Receptor ELISA Kit