Description
Apolipoprotein E (APOE) is a protein involved in the metabolism of fats in the body. It is implicated in Alzheimer's disease and cardiovascular disease. APOE is polymorphic, with three major alleles (epsilon 2, epsilon 3, and epsilon 4): APOE-ε2 (cys112, cys158), APOE-ε3 (cys112, arg158), and APOE-ε4 (arg112, arg158).Although these allelic forms differ from each other by only one or two amino acids at positions 112 and 158, these differences alter APOE structure and function