Fig 1: Inhibition of high glucose-induced oxidative stress and inflammation through suppression of PKC/HMGB1/RAGE/NFκB pathway by verbascoside. (A) SOD and (B) 8-OHdG assays were used to assess oxidative stress of high glucose-cultured cells following inhibition of PKC/HMGB1/RAGE/NFκB signaling; the high glucose-elicited production of IL-6 (C) and IL-1β (D) were downregulated in cells treated with verbascoside, NAC, or PKC inhibitor. * indicates p < 0.05 compared to the control group (CON); # indicates p < 0.05 compared to the high glucose group (HG).
Fig 2: The concentration of IL-6, TSLP, and TGF-β in plasma. Data presented as the mean ± SD. CRSsNP—chronic rhinosinusitis without nasal polyposis; CRSwNP—chronic rhinosinusitis with nasal polyposis; IL-6—interleukin 6; TGF-β—transforming growth factor β; TSLP—thymic stromal lymphopoietin. CRSsNP n = 15; CRSwNP n = 15; control group n = 10. Lines connect comparison groups with a p-value denoting the significant difference and pair-wise comparisons. Statistical analysis between investigated groups—two-sided Mann–Whitney U test (independent data).
Supplier Page from Bioss Inc. for Human IL-6 ELISA Kit