Fig 1: Effect of DAPA alone or in combination with DORSO or EX-527 on OVX/D-Gal-induced histopathological alterations as well as AD hallmarks (p-Tau and BACE1). a Representative H&E photomicrographs, b illustrative Nissl-stained photomicrographs, and c photomicrographs of p-Tau immuno-histochemical expression. Magnifications: ×400. Bar charts representing d intact neurons and e p-Tau positive cells as well as f BACE1 content in hippocampi of each group where each bar with vertical line illustrating the mean ± SD (n = 3–6). *vs. SO, @vs. OVX/D-Gal, #vs. DAPA, ßvs. DAPA + DORSO (one-way ANOVA followed by Tukey’s post hoc test, P < 0.05)