Description
Product Characteristics: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of MCP1 in serum, plasma, tissue homogenates, cell lysates, cell culture supernates. Due to the 82% homology of the sequence between mouse and rat, the kit can be used to detect mouse and rat samples.
Target Information: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2008]