Description
Human Tau [pT231] is a microtubule-associated protein of considerable importance to neuronal axons of vertebrate brain. Human Tau [pT231] exists as six different isoforms that result from alternative splicing of a single transcript derived from a gene located on chromosome 17. The molecular weights of the tau isoforms range from 48–68 kDa. Human Tau [pT231] protein is highly soluble and normally attached to axonal microtubules. Tau stabilizes the microtubules and makes them rigid. Human Tau [pT231] interacts with actin in the cytoskeleton and neuronal outgrowth, anchors enzymes such as protein kinases and phosphatases, and regulates intracellular vesicle transport