Fig 1: Bivariate correlations between the peak fatty acid oxidation rate (PFO) measured during fasted, incremental cycling, fatty acid oxidation during the first 30 min of prolonged, fed-state cycling (early FO), and 90–120 min of prolonged, fed-state cycling (late FO) and vastus lateralis carnitine palmitoyltransferase 1 (CPT1), carnitine palmitoyltransferase 2 (CPT2), fatty acid binding protein 1 (FABPpm), cluster of differentiation 36 (CD36), fatty acid transporter 1 (FATP1), and fatty acid transport 4 (FATP4). Circles denote Pearson’s correlation coefficient, and triangles ‘ρ’ denote Spearman’s rank-order correlation coefficient, with 95% confidence intervals shown by the solid lines. Colours denote statistical significance (P < 0.05)
Fig 2: Modelling analysis with stepwise selection for peak fatty acid oxidation rate during fasted, incremental cycling (PFO), mean fatty acid oxidation during the first 30 min of prolonged, fed-state cycling (early FO), and mean fatty acid oxidation during 90–120 min of prolonged, fed-state cycling (late FO). Fitted model values compared with measured values are shown in (A), (C), and (E). Standardised coefficients with 95% confidence intervals are shown in (B), (D), and (F). Adj R2, Adjusted R2 value; CD36, cluster of differentiation 36/SR-B3 (previously SR-B2); CPT1, carnitine palmitoyltransferase 1; EE, energy expenditure; FABPpm, fatty acid binding protein plasma membrane; FATP1, fatty acid transport protein 1; FATP4, fatty acid transport protein 4; RMSE, root mean square error
Fig 3: Differences in cerebrospinal fluid (A) alpha-2-macroglobin, (B) apolipoprotein A1, (C) CD36, and (D) haptoglobin levels between the favourable and unfavourable course groups in the verification MS cohort, measured by enzyme-linked immunosorbent assays.Two-tailed Student’s t-test; P<0.05, significant. ARMSS, age-related MS severity.
Fig 4: Schematic model of proteins involved in fatty acid transport in skeletal muscle. CD36, cluster of differentiation 36/SR-B3 (previously SR-B2); CPT1, carnitine palmitoyltransferase 1; CPT2, carnitine palmitoyltransferase 2; FABPpm, fatty acid binding protein plasma membrane, plasma membrane; FATP1, fatty acid transport protein 1; FATP4, fatty acid transport protein 4, FATP4; TCA, tricarboxylic acid. We acknowledge that the specific localisation of FATP1 is debated [14, 15, 48]
Fig 5: A Fatty acid oxidation rates in 12-week-old male CD36 knock-out (KO) mice and wild type (WT) littermates during a maximal treadmill running test. WT n = 4 and CD36 KO n = 6. B–D Contraction force (% of initial value) (B), palmitate uptake (C), and palmitate oxidation (D) in soleus muscle from 12-week-old male CD36 knock-out (KO) mice and wild type (WT) littermates at rest and during muscle contractions ex vivo. WT n = 8 and CD36 KO n = 9. ##, ###Significantly different (P < 0.01/P < 0.001) from rest within WT. *,***Significantly different (P < 0.05/P < 0.001) from WT within contracted. Data are mean ± SD. CD36, cluster of differentiation 36/SR-B3 (previously SR-B2)
Supplier Page from Abcam for Human CD36 ELISA Kit