Fig 1: Inhibition of SIRT3 signaling abolishes the protective effect of DEX during pro-inflammatory cytokine release induced by LPS. Animals were treated as in Figure 3 and then serum pro-inflammatory cytokines were measured by ELISA, including (A) tumor necrosis factor-α (TNF-α), (B) interleukin-6 (IL-6), (C) IL-5, (D) IL-1β, (E) IL-18 and (F) IL-17. The data are presented as mean ± SD (n = 3). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.