Fig 1: Results of Mendelian randomization studies. (A) Causal association between FCN2, DEFA1 and AMI. The bold numbers in the table indicate statistically significant results (p < 0.05). (B and C) Scatterplot: The x-axis shows the effect of SNPs on exposure, while the y-axis shows the effect of SNPs on the outcome. A positive slope indicates that the exposure factor adversely affects the outcome. (D and E) Forest plot: Values greater than 0 imply a positive association between the SNP and the outcome, whereas values less than 0 suggest a negative association. (F and G) Funnel plot. (H and I) Leave-one-out analysis: No instrumental variables were excluded, and the models’ effects remained statistically significant without significant deviations.
Fig 2: Clinical ELISA and external GEO dataset validation of DEPs up-regulated core proteins. (A) Statistical charts of ELISA validation for PCOLCE, FCN2, REG1A, DEFA1, and CRTAC1; (B-F) Expression levels and combined ROC curves of PCOLCE, FCN2, REG1A, DEFA1, and CRTAC1 in external GEO datasets GSE66360, GSE48060, GSE5406, GSE57388, and GSE57345. Control: healthy individuals (n = 120). AMI: acute myocardial infarction patients (n = 120). Compared to the control group, *p < 0.05, **p < 0.01.
Supplier Page from Thermo Fisher Scientific for Human Ficolin-2 ELISA Kit