Fig 1: The rs838133 minor allele does not affect FGF21 receptor and FAP levels. a) rs838133 is not associated with KLB gene expression in the liver based on the Genotype-Tissue Expression (GTEx) data and the GEO dataset (GEO: GSE32504 and GSE39036). b) No difference was observed in steady-state KLB mRNA expression levels between stably expressing cells of the two alleles of rs838133. c) This variant was not associated with KLB gene expression in adipose tissue from the GTEx database. Circulating KLB concentration was not significantly different between patients with d) MAFLD (n = 200) and healthy individuals (n = 44), or e) according to rs838133 genotype in patients with MAFLD. f) rs838133 is not associated with FGFR1 gene expression in adipose tissue from the GTEx database. rs838133 is not associated with FAP gene expression in the liver in g) both the GTEx database and the GEO dataset or in h) adipose tissue. i) Circulating FAP concentration was higher in patients with MAFLD (n = 200) compared to controls (n = 44). j) In patients with MAFLD, FAP serum levels were not associated with rs838133.