Fig 1: Knocking out Csde1 changed the levels of cytokines and immunoglobulin.A–D Flow cytometry analysis of B lymphocyte cells in the bone marrow, spleen, blood and tumor tissues. Representative images and quantification are shown. Quantification of the levels of cytokines, including CCL22, GM-CSF, IL-2, IL-10 and TNF-α, in the plasma (E) and tumors (F). Quantification of immunoglobulin levels, including IgA, IgD, IgE, IgG and IgM, in plasma (G) and tumors (H). *P < 0.05, **P < 0.01,***P < 0.001, #: not significant.