Fig 1: Immunohistochemical staining images. The 0.5% and 2.5% PI irrigation increased TGF‐β1, IL10 expression and decreased IL6 expression, as compared with the 0% PI group at 14 days. The 5% PI irrigation had the opposite effects. Images ×100; original scale bar, 200 μm.
Fig 2: Effect of rutin on the pulmonary expression levels of (A) rno-miR-9a-5p, (B) Nfkb1, and some related downstream genes, including (C) Ptgs2, (D) Il10, (E) Il18, and (F) Ifng. BLM, Bleomycin; rutin100, Rutin at a dose of 100 mg; rutin200, Rutin at a dose of 200 mg; Nfkb1, Nuclear factor kappa B subunit 1; Ptgs2, Prostaglandin-endoperoxide synthase 2; Il10, Interleukin-10; Il18, Interleukin-18; Ifng, Interferon-gamma. In multiple comparisons, a p < 0.05 vs. normal control group, b p < 0.05 vs. BLM-induced group, and c p < 0.05 vs. BLM + rutin100 group. n = 6 for each experimental group. Bar length represents the mean value for each group, with error bars depicting standard error of mean.
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